The biosynthesis of vitamin E in the bacteria escherichia coli
The lipid antioxidant vitamin E is among the supplements essential for humans and animals. Its biosynthesis pathways in plants and cyanobacteria have been elucidated and studied, cloned and expressed in order to enhance the vitamin E contents of producer crops. For decades, Escherichia coli has been...
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| Format: | Thesis |
| Language: | English |
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2014
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| Online Access: | http://hdl.handle.net/10356/61685 |
| _version_ | 1811685260531859456 |
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| author | Lieviant, Jane Andrea |
| author2 | Song Hao |
| author_facet | Song Hao Lieviant, Jane Andrea |
| author_sort | Lieviant, Jane Andrea |
| collection | NTU |
| description | The lipid antioxidant vitamin E is among the supplements essential for humans and animals. Its biosynthesis pathways in plants and cyanobacteria have been elucidated and studied, cloned and expressed in order to enhance the vitamin E contents of producer crops. For decades, Escherichia coli has been the primary workhorse for recombinant pharmaceuticals, especially for small molecules and proteins not requiring complex post-translational modifications. This work reviews the biosynthesis of tocochromanols, their functions, and past efforts in engineering the pathway, and the possibilities for E. coli as the optimal host system. |
| first_indexed | 2024-10-01T04:41:42Z |
| format | Thesis |
| id | ntu-10356/61685 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:41:42Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/616852023-03-03T16:01:16Z The biosynthesis of vitamin E in the bacteria escherichia coli Lieviant, Jane Andrea Song Hao School of Chemical and Biomedical Engineering DRNTU::Science::Biological sciences::Molecular biology The lipid antioxidant vitamin E is among the supplements essential for humans and animals. Its biosynthesis pathways in plants and cyanobacteria have been elucidated and studied, cloned and expressed in order to enhance the vitamin E contents of producer crops. For decades, Escherichia coli has been the primary workhorse for recombinant pharmaceuticals, especially for small molecules and proteins not requiring complex post-translational modifications. This work reviews the biosynthesis of tocochromanols, their functions, and past efforts in engineering the pathway, and the possibilities for E. coli as the optimal host system. Master of Science (Biomedical Engineering) 2014-08-12T02:32:32Z 2014-08-12T02:32:32Z 2014 2014 Thesis http://hdl.handle.net/10356/61685 en 40 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Molecular biology Lieviant, Jane Andrea The biosynthesis of vitamin E in the bacteria escherichia coli |
| title | The biosynthesis of vitamin E in the bacteria escherichia coli |
| title_full | The biosynthesis of vitamin E in the bacteria escherichia coli |
| title_fullStr | The biosynthesis of vitamin E in the bacteria escherichia coli |
| title_full_unstemmed | The biosynthesis of vitamin E in the bacteria escherichia coli |
| title_short | The biosynthesis of vitamin E in the bacteria escherichia coli |
| title_sort | biosynthesis of vitamin e in the bacteria escherichia coli |
| topic | DRNTU::Science::Biological sciences::Molecular biology |
| url | http://hdl.handle.net/10356/61685 |
| work_keys_str_mv | AT lieviantjaneandrea thebiosynthesisofvitamineinthebacteriaescherichiacoli AT lieviantjaneandrea biosynthesisofvitamineinthebacteriaescherichiacoli |