Feasibility study of ocular implants for HCMV retinitis treatment

The human cytomegalovirus usually exhibits life-long persistence. Although it is subclinical for healthy individuals, the virus can cause severe adverse effects on those who are immunoincompetent, such as AIDS patients, which could lead to huamn cytomegalovirus retinits. The retina would be inflamme...

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Bibliographic Details
Main Author: Huang, Xue Wei
Other Authors: Terry W.J. Steele
Format: Final Year Project (FYP)
Language:English
Published: 2015
Subjects:
Online Access:http://hdl.handle.net/10356/62475
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author Huang, Xue Wei
author2 Terry W.J. Steele
author_facet Terry W.J. Steele
Huang, Xue Wei
author_sort Huang, Xue Wei
collection NTU
description The human cytomegalovirus usually exhibits life-long persistence. Although it is subclinical for healthy individuals, the virus can cause severe adverse effects on those who are immunoincompetent, such as AIDS patients, which could lead to huamn cytomegalovirus retinits. The retina would be inflammed and result in blindness. Current forms of treatment include administering ganciclovir through various routes such as oral ingestion or intravitreal injections. Biodegradable implants offer advantages such as the ability to provide a constant therapeutic dose and zero dependency on patient compliance. While most research focused on producing biodegradable ganciclovir implants, this study proposed that the prodrug valganciclovir could have increase bioavailability and thus a better candidate as the drug for treatment. Hence valganciclovir was loaded in varying concentrations into different formulations of polymer blends to determine a suitable combination for a controlled release of the drug into the eye. The implants were produced from extrusion, a solvent free method, so as to have manufacturing conditions closer to those needed for mass production. In vitro release studies were conducted over 14 days and formulations with PCL/PLGA 70/30 and 3% or 10% drug load were found to be suitable candidates for future research. This was a preliminary study, thus further research including conducting in vitro release study until all of the drug is released as well as optimizing extrusion conditions are needed to attain the best implant design for the application of treating the virus in the eye.
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spelling ntu-10356/624752023-03-04T15:37:52Z Feasibility study of ocular implants for HCMV retinitis treatment Huang, Xue Wei Terry W.J. Steele School of Materials Science and Engineering DRNTU::Engineering::Materials::Biomaterials The human cytomegalovirus usually exhibits life-long persistence. Although it is subclinical for healthy individuals, the virus can cause severe adverse effects on those who are immunoincompetent, such as AIDS patients, which could lead to huamn cytomegalovirus retinits. The retina would be inflammed and result in blindness. Current forms of treatment include administering ganciclovir through various routes such as oral ingestion or intravitreal injections. Biodegradable implants offer advantages such as the ability to provide a constant therapeutic dose and zero dependency on patient compliance. While most research focused on producing biodegradable ganciclovir implants, this study proposed that the prodrug valganciclovir could have increase bioavailability and thus a better candidate as the drug for treatment. Hence valganciclovir was loaded in varying concentrations into different formulations of polymer blends to determine a suitable combination for a controlled release of the drug into the eye. The implants were produced from extrusion, a solvent free method, so as to have manufacturing conditions closer to those needed for mass production. In vitro release studies were conducted over 14 days and formulations with PCL/PLGA 70/30 and 3% or 10% drug load were found to be suitable candidates for future research. This was a preliminary study, thus further research including conducting in vitro release study until all of the drug is released as well as optimizing extrusion conditions are needed to attain the best implant design for the application of treating the virus in the eye. Bachelor of Engineering (Materials Engineering) 2015-04-08T04:25:53Z 2015-04-08T04:25:53Z 2015 2015 Final Year Project (FYP) http://hdl.handle.net/10356/62475 en Nanyang Technological University 45 p. application/pdf
spellingShingle DRNTU::Engineering::Materials::Biomaterials
Huang, Xue Wei
Feasibility study of ocular implants for HCMV retinitis treatment
title Feasibility study of ocular implants for HCMV retinitis treatment
title_full Feasibility study of ocular implants for HCMV retinitis treatment
title_fullStr Feasibility study of ocular implants for HCMV retinitis treatment
title_full_unstemmed Feasibility study of ocular implants for HCMV retinitis treatment
title_short Feasibility study of ocular implants for HCMV retinitis treatment
title_sort feasibility study of ocular implants for hcmv retinitis treatment
topic DRNTU::Engineering::Materials::Biomaterials
url http://hdl.handle.net/10356/62475
work_keys_str_mv AT huangxuewei feasibilitystudyofocularimplantsforhcmvretinitistreatment