Computational analysis and prediction of specific genomic regions forming R-loop structure and chromosomal variations associated with cancer
An R-loop is a structure formed co-transcriptionally between a nascent RNA and its template DNA strand, leaving the non-template DNA strand unpaired. I hypothesized that R-loops could form in many genes in mammalians, associate with transcription and genetic instability. I developed a quantitative m...
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| Format: | Thesis |
| Language: | English |
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2015
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| Online Access: | https://hdl.handle.net/10356/62554 |