Regulation of smooth muscle cells using UV embossed microchannelled polymeric films
The reconstruction of a functional vascular tunica media, with circumferentially oriented contractile smooth muscle cells (SMCs) and extracellular matrix, appropriate mechanical properties and vasoactivity has yet to be demonstrated for tissue engineering of small diameter blood vessels. Synthetic S...
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| Formato: | Thesis |
| Publicado em: |
2008
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| Acesso em linha: | https://hdl.handle.net/10356/6361 |
| _version_ | 1826122949981110272 |
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| author | Shen, Jinye |
| author2 | Chan Bee Eng, Mary |
| author_facet | Chan Bee Eng, Mary Shen, Jinye |
| author_sort | Shen, Jinye |
| collection | NTU |
| description | The reconstruction of a functional vascular tunica media, with circumferentially oriented contractile smooth muscle cells (SMCs) and extracellular matrix, appropriate mechanical properties and vasoactivity has yet to be demonstrated for tissue engineering of small diameter blood vessels. Synthetic SMC is desired for cell proliferation needed for vessel remodeling but the contractile phenotype is necessary for sufficient vasoactivity and inhibition of neoinitima formation. The switch of SMC phenotype from synthetic to contractile at the appropriate cell development stage has been hypothesized to be necessary for producing a functional vascular tunica media. |
| first_indexed | 2024-10-01T05:56:37Z |
| format | Thesis |
| id | ntu-10356/6361 |
| institution | Nanyang Technological University |
| last_indexed | 2024-10-01T05:56:37Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | ntu-10356/63612023-03-11T17:46:04Z Regulation of smooth muscle cells using UV embossed microchannelled polymeric films Shen, Jinye Chan Bee Eng, Mary School of Mechanical and Aerospace Engineering DRNTU::Engineering::Bioengineering The reconstruction of a functional vascular tunica media, with circumferentially oriented contractile smooth muscle cells (SMCs) and extracellular matrix, appropriate mechanical properties and vasoactivity has yet to be demonstrated for tissue engineering of small diameter blood vessels. Synthetic SMC is desired for cell proliferation needed for vessel remodeling but the contractile phenotype is necessary for sufficient vasoactivity and inhibition of neoinitima formation. The switch of SMC phenotype from synthetic to contractile at the appropriate cell development stage has been hypothesized to be necessary for producing a functional vascular tunica media. DOCTOR OF PHILOSOPHY (MAE) 2008-09-17T11:12:53Z 2008-09-17T11:12:53Z 2008 2008 Thesis Shen, J. (2008). Regulation of smooth muscle cells using UV embossed microchannelled polymeric films. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/6361 10.32657/10356/6361 Nanyang Technological University application/pdf |
| spellingShingle | DRNTU::Engineering::Bioengineering Shen, Jinye Regulation of smooth muscle cells using UV embossed microchannelled polymeric films |
| title | Regulation of smooth muscle cells using UV embossed microchannelled polymeric films |
| title_full | Regulation of smooth muscle cells using UV embossed microchannelled polymeric films |
| title_fullStr | Regulation of smooth muscle cells using UV embossed microchannelled polymeric films |
| title_full_unstemmed | Regulation of smooth muscle cells using UV embossed microchannelled polymeric films |
| title_short | Regulation of smooth muscle cells using UV embossed microchannelled polymeric films |
| title_sort | regulation of smooth muscle cells using uv embossed microchannelled polymeric films |
| topic | DRNTU::Engineering::Bioengineering |
| url | https://hdl.handle.net/10356/6361 |
| work_keys_str_mv | AT shenjinye regulationofsmoothmusclecellsusinguvembossedmicrochannelledpolymericfilms |