Delivery of arbutin with micellar transdermal technology for the suppression of melanin production
Hyperpigmentation is characterized by heighten production or accumulation of melanin due to increased numbers of melanocytes, melanocytic dendrites or activity of melanogenic enzymes and could be easily identified by the emergence of different shades of either reddish-purplish or brown lesions. Arbu...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
2015
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/64415 |
| _version_ | 1826111699911966720 |
|---|---|
| author | Liang, Ke |
| author2 | Xu Chen Jie |
| author_facet | Xu Chen Jie Liang, Ke |
| author_sort | Liang, Ke |
| collection | NTU |
| description | Hyperpigmentation is characterized by heighten production or accumulation of melanin due to increased numbers of melanocytes, melanocytic dendrites or activity of melanogenic enzymes and could be easily identified by the emergence of different shades of either reddish-purplish or brown lesions. Arbutin which arises as the most effective drugs, were encapsulated within micelle and delivered into B16-F10 mouse melanoma cells to investigate on effectiveness of this drug delivery system. The result has shown that micellar Arbutin was a bit less efficient compared with free arbutin, but still effective compared with blank micelles and the control. And micellar Arbutin also is able to delivery Arbutin through the skin (0.027mg/ml within 24h), after using porcine skin in vitro skin permeation study. |
| first_indexed | 2024-10-01T02:55:05Z |
| format | Thesis |
| id | ntu-10356/64415 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:55:05Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/644152023-03-03T15:57:44Z Delivery of arbutin with micellar transdermal technology for the suppression of melanin production Liang, Ke Xu Chen Jie School of Chemical and Biomedical Engineering Urah Resources Pte Ltd DRNTU::Engineering::Bioengineering Hyperpigmentation is characterized by heighten production or accumulation of melanin due to increased numbers of melanocytes, melanocytic dendrites or activity of melanogenic enzymes and could be easily identified by the emergence of different shades of either reddish-purplish or brown lesions. Arbutin which arises as the most effective drugs, were encapsulated within micelle and delivered into B16-F10 mouse melanoma cells to investigate on effectiveness of this drug delivery system. The result has shown that micellar Arbutin was a bit less efficient compared with free arbutin, but still effective compared with blank micelles and the control. And micellar Arbutin also is able to delivery Arbutin through the skin (0.027mg/ml within 24h), after using porcine skin in vitro skin permeation study. Master of Science (Biomedical Engineering) 2015-05-26T07:21:36Z 2015-05-26T07:21:36Z 2015 2015 Thesis http://hdl.handle.net/10356/64415 en 33 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Bioengineering Liang, Ke Delivery of arbutin with micellar transdermal technology for the suppression of melanin production |
| title | Delivery of arbutin with micellar transdermal technology for the suppression of melanin production |
| title_full | Delivery of arbutin with micellar transdermal technology for the suppression of melanin production |
| title_fullStr | Delivery of arbutin with micellar transdermal technology for the suppression of melanin production |
| title_full_unstemmed | Delivery of arbutin with micellar transdermal technology for the suppression of melanin production |
| title_short | Delivery of arbutin with micellar transdermal technology for the suppression of melanin production |
| title_sort | delivery of arbutin with micellar transdermal technology for the suppression of melanin production |
| topic | DRNTU::Engineering::Bioengineering |
| url | http://hdl.handle.net/10356/64415 |
| work_keys_str_mv | AT liangke deliveryofarbutinwithmicellartransdermaltechnologyforthesuppressionofmelaninproduction |