Nanocarriers for drug delivery : liposomes and polymersomes
According to the World Health Organization (WHO), glaucoma is the world’s second leading cause of blindness and it can affect anyone from any race, gender and age. Current treatment methods for glaucoma include the use of topical daily eye drops, laser therapy and surgery. Topical daily eye drop...
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| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2016
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| Online Access: | http://hdl.handle.net/10356/66360 |
| _version_ | 1811693836842303488 |
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| author | Lee, Ru Xuan |
| author2 | Subramanian Venkatraman |
| author_facet | Subramanian Venkatraman Lee, Ru Xuan |
| author_sort | Lee, Ru Xuan |
| collection | NTU |
| description | According to the World Health Organization (WHO), glaucoma is the world’s second
leading cause of blindness and it can affect anyone from any race, gender and age.
Current treatment methods for glaucoma include the use of topical daily eye drops, laser
therapy and surgery. Topical daily eye drop is often used in glaucoma treatment.
However less than 5% of the drug permeates and enters the eye due to the physiological
and anatomical of eye barriers. Hence it usually leads to suboptimal control of intraocular
pressure (IOP) and poor patient compliance.
To overcome these drawbacks, sustained drug delivery is warranted that could be
beneficial for ocular diseases such as glaucoma. In this project, liposomes and
polymersomes are synthesized as nanocarriers and its loading capability is explored and
will be evaluated in in-vitro conditions. Three different lipids are used to formulate
liposomes which are then loaded with varying concentrations of latanoprost drug. Their
size stability and release profiles are then studied and compared. Loading capability of
polymersomes is also explored using 5(6)-carboxyfluorescein (CF) dye. The size and
morphology of the CF-loaded polymersomes as well as its release profile are studied.
Liposomes have shown promising results for sustained delivery while more studies are
require to determine and understand the optimal conditions for loading and sustained
drug delivery using polymersomes. |
| first_indexed | 2024-10-01T06:58:01Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/66360 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:58:01Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/663602023-03-04T15:41:02Z Nanocarriers for drug delivery : liposomes and polymersomes Lee, Ru Xuan Subramanian Venkatraman School of Materials Science and Engineering DRNTU::Engineering According to the World Health Organization (WHO), glaucoma is the world’s second leading cause of blindness and it can affect anyone from any race, gender and age. Current treatment methods for glaucoma include the use of topical daily eye drops, laser therapy and surgery. Topical daily eye drop is often used in glaucoma treatment. However less than 5% of the drug permeates and enters the eye due to the physiological and anatomical of eye barriers. Hence it usually leads to suboptimal control of intraocular pressure (IOP) and poor patient compliance. To overcome these drawbacks, sustained drug delivery is warranted that could be beneficial for ocular diseases such as glaucoma. In this project, liposomes and polymersomes are synthesized as nanocarriers and its loading capability is explored and will be evaluated in in-vitro conditions. Three different lipids are used to formulate liposomes which are then loaded with varying concentrations of latanoprost drug. Their size stability and release profiles are then studied and compared. Loading capability of polymersomes is also explored using 5(6)-carboxyfluorescein (CF) dye. The size and morphology of the CF-loaded polymersomes as well as its release profile are studied. Liposomes have shown promising results for sustained delivery while more studies are require to determine and understand the optimal conditions for loading and sustained drug delivery using polymersomes. Bachelor of Engineering (Materials Engineering) 2016-03-30T04:27:26Z 2016-03-30T04:27:26Z 2016 Final Year Project (FYP) http://hdl.handle.net/10356/66360 en Nanyang Technological University 51 p. application/pdf |
| spellingShingle | DRNTU::Engineering Lee, Ru Xuan Nanocarriers for drug delivery : liposomes and polymersomes |
| title | Nanocarriers for drug delivery : liposomes and polymersomes |
| title_full | Nanocarriers for drug delivery : liposomes and polymersomes |
| title_fullStr | Nanocarriers for drug delivery : liposomes and polymersomes |
| title_full_unstemmed | Nanocarriers for drug delivery : liposomes and polymersomes |
| title_short | Nanocarriers for drug delivery : liposomes and polymersomes |
| title_sort | nanocarriers for drug delivery liposomes and polymersomes |
| topic | DRNTU::Engineering |
| url | http://hdl.handle.net/10356/66360 |
| work_keys_str_mv | AT leeruxuan nanocarriersfordrugdeliveryliposomesandpolymersomes |