The role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in colorectal cancer cells
In colorectal cancer (CRC), plasma levels of LRG1 is observed to be increased in female patients before their diagnosis of CRC. In addition, LRG1 is reported to positively correlate colonic adenoma in a rodent model of CRC. More recently, LRG1 was reported to be able to modulate epithelial-mesenchym...
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| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2016
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| Online Access: | http://hdl.handle.net/10356/68248 |
| _version_ | 1811683753837199360 |
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| author | Chew, Clement Kai Hong |
| author2 | Wang Xiaomeng |
| author_facet | Wang Xiaomeng Chew, Clement Kai Hong |
| author_sort | Chew, Clement Kai Hong |
| collection | NTU |
| description | In colorectal cancer (CRC), plasma levels of LRG1 is observed to be increased in female patients before their diagnosis of CRC. In addition, LRG1 is reported to positively correlate colonic adenoma in a rodent model of CRC. More recently, LRG1 was reported to be able to modulate epithelial-mesenchymal transition of some CRC cell lines. Attempts to elucidate how LRG1 modulates TGF-β signalling, proliferation rate and cell cycle in HCT-15 and HT-29 CRC cell lines were made via western blot, LRG1 overexpression and MTS proliferation assays. Preliminary data hints that LRG1 upregulates TGF-β signaling molecules promote proliferation of HCT-15 and HT-29 CRC cells lines. This presents LRG1 a potential cancer drug target in the context of CRC. |
| first_indexed | 2024-10-01T04:17:45Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/68248 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:17:45Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/682482023-02-28T18:07:17Z The role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in colorectal cancer cells Chew, Clement Kai Hong Wang Xiaomeng School of Biological Sciences DRNTU::Science In colorectal cancer (CRC), plasma levels of LRG1 is observed to be increased in female patients before their diagnosis of CRC. In addition, LRG1 is reported to positively correlate colonic adenoma in a rodent model of CRC. More recently, LRG1 was reported to be able to modulate epithelial-mesenchymal transition of some CRC cell lines. Attempts to elucidate how LRG1 modulates TGF-β signalling, proliferation rate and cell cycle in HCT-15 and HT-29 CRC cell lines were made via western blot, LRG1 overexpression and MTS proliferation assays. Preliminary data hints that LRG1 upregulates TGF-β signaling molecules promote proliferation of HCT-15 and HT-29 CRC cells lines. This presents LRG1 a potential cancer drug target in the context of CRC. Bachelor of Science in Biological Sciences 2016-05-25T03:57:17Z 2016-05-25T03:57:17Z 2016 Final Year Project (FYP) http://hdl.handle.net/10356/68248 en Nanyang Technological University 39 p. application/pdf |
| spellingShingle | DRNTU::Science Chew, Clement Kai Hong The role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in colorectal cancer cells |
| title | The role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in colorectal cancer cells |
| title_full | The role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in colorectal cancer cells |
| title_fullStr | The role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in colorectal cancer cells |
| title_full_unstemmed | The role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in colorectal cancer cells |
| title_short | The role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in colorectal cancer cells |
| title_sort | role of leucine rich alpha 2 glycoprotein 1 lrg1 in colorectal cancer cells |
| topic | DRNTU::Science |
| url | http://hdl.handle.net/10356/68248 |
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