Graphene quantum dot as drug carriers
Graphene quantum dot (GQD) is a nanoscale fluorescent particle which has various applications. It is synthesized from a suitable carbon precursor by either a top- down or a bottom- up approach like microwave- assisted, solvothermal, cage opening and other exfoliation reactions. For this project, GQD...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2016
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| Online Access: | http://hdl.handle.net/10356/68347 |
| _version_ | 1811688099301818368 |
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| author | Lee, Angeline Jia Hui |
| author2 | Chen Peng |
| author_facet | Chen Peng Lee, Angeline Jia Hui |
| author_sort | Lee, Angeline Jia Hui |
| collection | NTU |
| description | Graphene quantum dot (GQD) is a nanoscale fluorescent particle which has various applications. It is synthesized from a suitable carbon precursor by either a top- down or a bottom- up approach like microwave- assisted, solvothermal, cage opening and other exfoliation reactions. For this project, GQDs were used and studied for as a drug carrier. The target cells are HeLa, which are cervical cancer cells. The optimal condition for the drug loading onto the GQDs occurred at pH 8 while drug release was triggered rapidly at pH 5.5 (tumor pH). This experimental result provides an indication that the loading and release of beta- Lapachone can be controlled by changes in the pH of the solution. This characteristic proves to be a great advantage as tumor cells are slightly acidic in nature. The biocompatibility assay ensured the non-cell toxic nature of GQDs. Based on the cell viability (MTT) test, the results showed that in the presence of free drug and beta- lapachone- loaded GQD there was a significant reduction in cancer cell viability. This study would thus prove the efficacy of GQDs as drug carriers to cancerous cells. |
| first_indexed | 2024-10-01T05:26:49Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/68347 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:26:49Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/683472023-03-03T15:36:18Z Graphene quantum dot as drug carriers Lee, Angeline Jia Hui Chen Peng School of Chemical and Biomedical Engineering DRNTU::Engineering Graphene quantum dot (GQD) is a nanoscale fluorescent particle which has various applications. It is synthesized from a suitable carbon precursor by either a top- down or a bottom- up approach like microwave- assisted, solvothermal, cage opening and other exfoliation reactions. For this project, GQDs were used and studied for as a drug carrier. The target cells are HeLa, which are cervical cancer cells. The optimal condition for the drug loading onto the GQDs occurred at pH 8 while drug release was triggered rapidly at pH 5.5 (tumor pH). This experimental result provides an indication that the loading and release of beta- Lapachone can be controlled by changes in the pH of the solution. This characteristic proves to be a great advantage as tumor cells are slightly acidic in nature. The biocompatibility assay ensured the non-cell toxic nature of GQDs. Based on the cell viability (MTT) test, the results showed that in the presence of free drug and beta- lapachone- loaded GQD there was a significant reduction in cancer cell viability. This study would thus prove the efficacy of GQDs as drug carriers to cancerous cells. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2016-05-25T07:07:37Z 2016-05-25T07:07:37Z 2016 Final Year Project (FYP) http://hdl.handle.net/10356/68347 en Nanyang Technological University 42 p. application/pdf |
| spellingShingle | DRNTU::Engineering Lee, Angeline Jia Hui Graphene quantum dot as drug carriers |
| title | Graphene quantum dot as drug carriers |
| title_full | Graphene quantum dot as drug carriers |
| title_fullStr | Graphene quantum dot as drug carriers |
| title_full_unstemmed | Graphene quantum dot as drug carriers |
| title_short | Graphene quantum dot as drug carriers |
| title_sort | graphene quantum dot as drug carriers |
| topic | DRNTU::Engineering |
| url | http://hdl.handle.net/10356/68347 |
| work_keys_str_mv | AT leeangelinejiahui graphenequantumdotasdrugcarriers |