A genomics-guided study of the biosynthesis of microbial secondary metabolites
Microorganisms such as filamentous fungi and actinomycetes are prolific producers of structurally diverse secondary metabolites. Many microbial natural products have been developed into commercially valuable compounds such as pharmaceutical agents. After several decades of screening for bioactive co...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
2016
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| Online Access: | https://hdl.handle.net/10356/68357 |
| _version_ | 1826130046200315904 |
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| author | Chakrabortti, Alolika |
| author2 | Liang Zhao-Xun |
| author_facet | Liang Zhao-Xun Chakrabortti, Alolika |
| author_sort | Chakrabortti, Alolika |
| collection | NTU |
| description | Microorganisms such as filamentous fungi and actinomycetes are prolific producers of structurally diverse secondary metabolites. Many microbial natural products have been developed into commercially valuable compounds such as pharmaceutical agents. After several decades of screening for bioactive compounds, the field of microbial natural product discovery is plagued with the problem of re-discovering already known compounds. To circumvent this challenge, we took a genomics-guided approach in this study to uncover the secondary metabolite synthesizing potential of the filamentous fungus Aspergillus westerdijkiae and the rare actinomycetes Nocardia jinanensis. The genome sequencing and characterization of certain secondary metabolism gene clusters described in this study sets the stage for exploring the full biosynthetic potential of the two highly prolific producers of secondary metabolite for the discovery of novel natural products and biosynthetic enzymes. |
| first_indexed | 2024-10-01T07:50:27Z |
| format | Thesis |
| id | ntu-10356/68357 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:50:27Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/683572023-02-28T18:48:00Z A genomics-guided study of the biosynthesis of microbial secondary metabolites Chakrabortti, Alolika Liang Zhao-Xun School of Biological Sciences DRNTU::Science::Biological sciences::Biochemistry Microorganisms such as filamentous fungi and actinomycetes are prolific producers of structurally diverse secondary metabolites. Many microbial natural products have been developed into commercially valuable compounds such as pharmaceutical agents. After several decades of screening for bioactive compounds, the field of microbial natural product discovery is plagued with the problem of re-discovering already known compounds. To circumvent this challenge, we took a genomics-guided approach in this study to uncover the secondary metabolite synthesizing potential of the filamentous fungus Aspergillus westerdijkiae and the rare actinomycetes Nocardia jinanensis. The genome sequencing and characterization of certain secondary metabolism gene clusters described in this study sets the stage for exploring the full biosynthetic potential of the two highly prolific producers of secondary metabolite for the discovery of novel natural products and biosynthetic enzymes. DOCTOR OF PHILOSOPHY (SBS) 2016-05-25T07:28:12Z 2016-05-25T07:28:12Z 2016 Thesis Chakrabortti, A. (2016). A genomics-guided study of the biosynthesis of microbial secondary metabolites. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/68357 10.32657/10356/68357 en 215 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Biochemistry Chakrabortti, Alolika A genomics-guided study of the biosynthesis of microbial secondary metabolites |
| title | A genomics-guided study of the biosynthesis of microbial secondary metabolites |
| title_full | A genomics-guided study of the biosynthesis of microbial secondary metabolites |
| title_fullStr | A genomics-guided study of the biosynthesis of microbial secondary metabolites |
| title_full_unstemmed | A genomics-guided study of the biosynthesis of microbial secondary metabolites |
| title_short | A genomics-guided study of the biosynthesis of microbial secondary metabolites |
| title_sort | genomics guided study of the biosynthesis of microbial secondary metabolites |
| topic | DRNTU::Science::Biological sciences::Biochemistry |
| url | https://hdl.handle.net/10356/68357 |
| work_keys_str_mv | AT chakraborttialolika agenomicsguidedstudyofthebiosynthesisofmicrobialsecondarymetabolites AT chakraborttialolika genomicsguidedstudyofthebiosynthesisofmicrobialsecondarymetabolites |