Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination

During early embryogenesis, vasculature development is essential for the survival of the organism. Semaphorin3E-PlexinD1 (Sema3E-PlexinD1) signaling plays a role in blood vessel growth and patterning. One of its function is to inhibit Notch signaling in stalk cells during tip cell selection in angio...

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Main Author: Goh, Joyce Wei Ting
Other Authors: Siti Azlinda Bte Amasha
Format: Final Year Project (FYP)
Language:English
Published: 2016
Subjects:
Online Access:http://hdl.handle.net/10356/69193
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author Goh, Joyce Wei Ting
author2 Siti Azlinda Bte Amasha
author_facet Siti Azlinda Bte Amasha
Goh, Joyce Wei Ting
author_sort Goh, Joyce Wei Ting
collection NTU
description During early embryogenesis, vasculature development is essential for the survival of the organism. Semaphorin3E-PlexinD1 (Sema3E-PlexinD1) signaling plays a role in blood vessel growth and patterning. One of its function is to inhibit Notch signaling in stalk cells during tip cell selection in angiogenesis. The ability of Sema3E-PlexinD1 signaling in downregulating Notch signaling leads us to hypothesize that Sema3E-PlexinD1 signaling affects arteriovenous cell fate determination in endothelial cells, through the inhibition of Notch signaling pathway. Hence, this study is the first step of testing this hypothesis by exploring the effects of Sema3E-PlexinD1 signaling on the mRNA expression of the members of the Notch signaling pathway.
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spelling ntu-10356/691932023-02-28T18:06:07Z Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination Goh, Joyce Wei Ting Siti Azlinda Bte Amasha School of Biological Sciences Duke-NUS Medical School BioSciences Research Centre Manvendra Kumar Singh DRNTU::Science During early embryogenesis, vasculature development is essential for the survival of the organism. Semaphorin3E-PlexinD1 (Sema3E-PlexinD1) signaling plays a role in blood vessel growth and patterning. One of its function is to inhibit Notch signaling in stalk cells during tip cell selection in angiogenesis. The ability of Sema3E-PlexinD1 signaling in downregulating Notch signaling leads us to hypothesize that Sema3E-PlexinD1 signaling affects arteriovenous cell fate determination in endothelial cells, through the inhibition of Notch signaling pathway. Hence, this study is the first step of testing this hypothesis by exploring the effects of Sema3E-PlexinD1 signaling on the mRNA expression of the members of the Notch signaling pathway. Bachelor of Science in Biological Sciences 2016-11-22T02:20:03Z 2016-11-22T02:20:03Z 2016 Final Year Project (FYP) http://hdl.handle.net/10356/69193 en Nanyang Technological University 34 p. application/pdf
spellingShingle DRNTU::Science
Goh, Joyce Wei Ting
Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination
title Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination
title_full Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination
title_fullStr Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination
title_full_unstemmed Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination
title_short Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination
title_sort role of semaphorin3e plexind1 signaling in endothelial cell fate determination
topic DRNTU::Science
url http://hdl.handle.net/10356/69193
work_keys_str_mv AT gohjoyceweiting roleofsemaphorin3eplexind1signalinginendothelialcellfatedetermination