Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination
During early embryogenesis, vasculature development is essential for the survival of the organism. Semaphorin3E-PlexinD1 (Sema3E-PlexinD1) signaling plays a role in blood vessel growth and patterning. One of its function is to inhibit Notch signaling in stalk cells during tip cell selection in angio...
Main Author: | |
---|---|
Other Authors: | |
Format: | Final Year Project (FYP) |
Language: | English |
Published: |
2016
|
Subjects: | |
Online Access: | http://hdl.handle.net/10356/69193 |
_version_ | 1811682343462633472 |
---|---|
author | Goh, Joyce Wei Ting |
author2 | Siti Azlinda Bte Amasha |
author_facet | Siti Azlinda Bte Amasha Goh, Joyce Wei Ting |
author_sort | Goh, Joyce Wei Ting |
collection | NTU |
description | During early embryogenesis, vasculature development is essential for the survival of the organism. Semaphorin3E-PlexinD1 (Sema3E-PlexinD1) signaling plays a role in blood vessel growth and patterning. One of its function is to inhibit Notch signaling in stalk cells during tip cell selection in angiogenesis. The ability of Sema3E-PlexinD1 signaling in downregulating Notch signaling leads us to hypothesize that Sema3E-PlexinD1 signaling affects arteriovenous cell fate determination in endothelial cells, through the inhibition of Notch signaling pathway. Hence, this study is the first step of testing this hypothesis by exploring the effects of Sema3E-PlexinD1 signaling on the mRNA expression of the members of the Notch signaling pathway. |
first_indexed | 2024-10-01T03:55:20Z |
format | Final Year Project (FYP) |
id | ntu-10356/69193 |
institution | Nanyang Technological University |
language | English |
last_indexed | 2024-10-01T03:55:20Z |
publishDate | 2016 |
record_format | dspace |
spelling | ntu-10356/691932023-02-28T18:06:07Z Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination Goh, Joyce Wei Ting Siti Azlinda Bte Amasha School of Biological Sciences Duke-NUS Medical School BioSciences Research Centre Manvendra Kumar Singh DRNTU::Science During early embryogenesis, vasculature development is essential for the survival of the organism. Semaphorin3E-PlexinD1 (Sema3E-PlexinD1) signaling plays a role in blood vessel growth and patterning. One of its function is to inhibit Notch signaling in stalk cells during tip cell selection in angiogenesis. The ability of Sema3E-PlexinD1 signaling in downregulating Notch signaling leads us to hypothesize that Sema3E-PlexinD1 signaling affects arteriovenous cell fate determination in endothelial cells, through the inhibition of Notch signaling pathway. Hence, this study is the first step of testing this hypothesis by exploring the effects of Sema3E-PlexinD1 signaling on the mRNA expression of the members of the Notch signaling pathway. Bachelor of Science in Biological Sciences 2016-11-22T02:20:03Z 2016-11-22T02:20:03Z 2016 Final Year Project (FYP) http://hdl.handle.net/10356/69193 en Nanyang Technological University 34 p. application/pdf |
spellingShingle | DRNTU::Science Goh, Joyce Wei Ting Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination |
title | Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination |
title_full | Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination |
title_fullStr | Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination |
title_full_unstemmed | Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination |
title_short | Role of Semaphorin3E-PlexinD1 signaling in endothelial cell fate determination |
title_sort | role of semaphorin3e plexind1 signaling in endothelial cell fate determination |
topic | DRNTU::Science |
url | http://hdl.handle.net/10356/69193 |
work_keys_str_mv | AT gohjoyceweiting roleofsemaphorin3eplexind1signalinginendothelialcellfatedetermination |