An investigation of polymersomes as nanocarriers for drug delivery
Considering its good stability and tunability of physicochemical properties, polymersomes have been explored as novel nanocarriers for many different biomedical applications. The poly(butadiene)-b-(ethylene oxide) (PBd-b-EO) is one of the popular choices for forming these self-assembled polymersomes...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2016
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/69196 |
| _version_ | 1811685550432714752 |
|---|---|
| author | Ou, Yi Hsuan |
| author2 | Subramanian Venkatraman |
| author_facet | Subramanian Venkatraman Ou, Yi Hsuan |
| author_sort | Ou, Yi Hsuan |
| collection | NTU |
| description | Considering its good stability and tunability of physicochemical properties, polymersomes have been explored as novel nanocarriers for many different biomedical applications. The poly(butadiene)-b-(ethylene oxide) (PBd-b-EO) is one of the popular choices for forming these self-assembled polymersomes. The aim of this study is to evaluate the characteristics, loading capacity and release profile of polymersomes synthesized from this copolymer with different molecular weights through two common formulation methods (co-solvent method and thin-film rehydration). Three copolymers of different molecular weight were used in this study to determine its effects on the properties of the polymersomes, and these vesicles were characterized by Dynamic Light Scattering (DLS) and cryogenic Transmission Electron Microscopy (Cryo-TEM). Their dual loading capacity was demonstrated, and in vitro release profile was established with Dexamethasone. The PBd(1.9)-b-EO(0.9) polymersomes from thin-film rehydration were found to demonstrate the sustained release over the course of 9 days, with reasonable drug quantity (0.07 to 0.32% w/w). Their long-term stability was observed over the course of 2 months under storage condition (4oC) which further suggest the vast potential of this polymersome as drug carrier in development of sustained release drug delivery. |
| first_indexed | 2024-10-01T04:46:18Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/69196 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:46:18Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/691962023-02-28T18:01:54Z An investigation of polymersomes as nanocarriers for drug delivery Ou, Yi Hsuan Subramanian Venkatraman School of Biological Sciences DRNTU::Science Considering its good stability and tunability of physicochemical properties, polymersomes have been explored as novel nanocarriers for many different biomedical applications. The poly(butadiene)-b-(ethylene oxide) (PBd-b-EO) is one of the popular choices for forming these self-assembled polymersomes. The aim of this study is to evaluate the characteristics, loading capacity and release profile of polymersomes synthesized from this copolymer with different molecular weights through two common formulation methods (co-solvent method and thin-film rehydration). Three copolymers of different molecular weight were used in this study to determine its effects on the properties of the polymersomes, and these vesicles were characterized by Dynamic Light Scattering (DLS) and cryogenic Transmission Electron Microscopy (Cryo-TEM). Their dual loading capacity was demonstrated, and in vitro release profile was established with Dexamethasone. The PBd(1.9)-b-EO(0.9) polymersomes from thin-film rehydration were found to demonstrate the sustained release over the course of 9 days, with reasonable drug quantity (0.07 to 0.32% w/w). Their long-term stability was observed over the course of 2 months under storage condition (4oC) which further suggest the vast potential of this polymersome as drug carrier in development of sustained release drug delivery. Bachelor of Science in Biological Sciences 2016-11-22T06:22:06Z 2016-11-22T06:22:06Z 2016 Final Year Project (FYP) http://hdl.handle.net/10356/69196 en Nanyang Technological University 59 p. application/pdf |
| spellingShingle | DRNTU::Science Ou, Yi Hsuan An investigation of polymersomes as nanocarriers for drug delivery |
| title | An investigation of polymersomes as nanocarriers for drug delivery |
| title_full | An investigation of polymersomes as nanocarriers for drug delivery |
| title_fullStr | An investigation of polymersomes as nanocarriers for drug delivery |
| title_full_unstemmed | An investigation of polymersomes as nanocarriers for drug delivery |
| title_short | An investigation of polymersomes as nanocarriers for drug delivery |
| title_sort | investigation of polymersomes as nanocarriers for drug delivery |
| topic | DRNTU::Science |
| url | http://hdl.handle.net/10356/69196 |
| work_keys_str_mv | AT ouyihsuan aninvestigationofpolymersomesasnanocarriersfordrugdelivery AT ouyihsuan investigationofpolymersomesasnanocarriersfordrugdelivery |