Development of therapeutic antibodies against SIRPα
Cancer can evade detection by the immune system through interactions with effector cells such as macrophages. CD47 acts as a “don’t eat me” signal for normal cells and is overexpressed in many cancer types. CD47 interacts with SIRPα on macrophages and inhibits phagocytosis. Disrupting the CD47-SIRPα...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2017
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| Online Access: | http://hdl.handle.net/10356/71532 |