Development of semiconducting polymers nanoparticles for photothermal therapy
Optical nano agents have been studied intensively and numerous therapeutic agents were developed in the past few decades for effective precision medicine. In this report, SPNs (near-infrared absorbing semiconducting polymer PCPDTBT with difunctional block copolymer surfactant F127) were synthesized...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2017
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| Online Access: | http://hdl.handle.net/10356/72056 |
| _version_ | 1826110375014170624 |
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| author | Ng, Ghim Hwee |
| author2 | Pu Kanyi |
| author_facet | Pu Kanyi Ng, Ghim Hwee |
| author_sort | Ng, Ghim Hwee |
| collection | NTU |
| description | Optical nano agents have been studied intensively and numerous therapeutic agents were developed in the past few decades for effective precision medicine. In this report, SPNs (near-infrared absorbing semiconducting polymer PCPDTBT with difunctional block copolymer surfactant F127) were synthesized by nanoprecipitation, and were used to analyze their photothermal imaging capability to treat in-vitro 4T1 tumour cells. The PCPDTBT- F127 SPNs had an average diameter of 26.65 ± 0.22 nm and for UV-Vis absorption, there were 2 absorptions peaks at 409 nm and 666 nm respectively. Confocal imaging showed PCPDTBT-F127 SPNs were able to enter 4T1 cells and it was mainly located in the lysosome. The SPNs possess great photostability, showed good biocompatibility and effective therapeutic results of killing 4T1 cells. Future work should be conducted in vivo, such as on mice subject, to prove PCPDTBT-F127 SPNs is a potential candidate for cancer therapeutic applications. |
| first_indexed | 2024-10-01T02:33:22Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/72056 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:33:22Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/720562023-03-03T15:32:08Z Development of semiconducting polymers nanoparticles for photothermal therapy Ng, Ghim Hwee Pu Kanyi School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering Optical nano agents have been studied intensively and numerous therapeutic agents were developed in the past few decades for effective precision medicine. In this report, SPNs (near-infrared absorbing semiconducting polymer PCPDTBT with difunctional block copolymer surfactant F127) were synthesized by nanoprecipitation, and were used to analyze their photothermal imaging capability to treat in-vitro 4T1 tumour cells. The PCPDTBT- F127 SPNs had an average diameter of 26.65 ± 0.22 nm and for UV-Vis absorption, there were 2 absorptions peaks at 409 nm and 666 nm respectively. Confocal imaging showed PCPDTBT-F127 SPNs were able to enter 4T1 cells and it was mainly located in the lysosome. The SPNs possess great photostability, showed good biocompatibility and effective therapeutic results of killing 4T1 cells. Future work should be conducted in vivo, such as on mice subject, to prove PCPDTBT-F127 SPNs is a potential candidate for cancer therapeutic applications. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2017-05-24T02:42:51Z 2017-05-24T02:42:51Z 2017 Final Year Project (FYP) http://hdl.handle.net/10356/72056 en Nanyang Technological University 43 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Bioengineering Ng, Ghim Hwee Development of semiconducting polymers nanoparticles for photothermal therapy |
| title | Development of semiconducting polymers nanoparticles for photothermal therapy |
| title_full | Development of semiconducting polymers nanoparticles for photothermal therapy |
| title_fullStr | Development of semiconducting polymers nanoparticles for photothermal therapy |
| title_full_unstemmed | Development of semiconducting polymers nanoparticles for photothermal therapy |
| title_short | Development of semiconducting polymers nanoparticles for photothermal therapy |
| title_sort | development of semiconducting polymers nanoparticles for photothermal therapy |
| topic | DRNTU::Engineering::Bioengineering |
| url | http://hdl.handle.net/10356/72056 |
| work_keys_str_mv | AT ngghimhwee developmentofsemiconductingpolymersnanoparticlesforphotothermaltherapy |