The hidden rule in argonaute protein loading : sequence specificity
Argonaute (AGO) proteins play an important role in gene regulation with small RNAs serving as guides to targets. The small RNA duplex structure and 5’ terminal nucleotide are the only known determinants of AGO loading efficacy, and AGOs are believed to load small RNAs independently of their sequence...
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | http://hdl.handle.net/10356/73227 |