Engineering of anti-cancer g-quadruplex nucleic acids and anti-bacterial protein fibers
Functional synthetic biopolymers are widely used in the therapeutic treatment and medical devices. This thesis consists of two parts focusing on nucleic acids and proteins respectively. In the first project, structural conformation and bioactivity of G-quadruplex-forming sequences, derived from a we...
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | http://hdl.handle.net/10356/73336 |
| _version_ | 1824454412666404864 |
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| author | Truong, Thi Hong Anh |
| author2 | Phan Anh Tuan |
| author_facet | Phan Anh Tuan Truong, Thi Hong Anh |
| author_sort | Truong, Thi Hong Anh |
| collection | NTU |
| description | Functional synthetic biopolymers are widely used in the therapeutic treatment and medical devices. This thesis consists of two parts focusing on nucleic acids and proteins respectively. In the first project, structural conformation and bioactivity of G-quadruplex-forming sequences, derived from a well-known aptamer AGRO100, was explored. Our findings on the novel G-quadruplex structures and their anti-proliferative activity against cancer cells might contribute in the development of oligonucleotides for therapeutic treatment. In the second project, a recombinant protein derived from elastin was synthesized and induced to self-assemble and form a fiber platform for silver nanoparticles formation. The silver-coated protein fibers exhibited the anti-bacterial properties on E. coli and S. aureus. This synthetic protein offers a novel biomaterial for an anti-bacterial coating in medical devices. |
| first_indexed | 2025-02-19T03:21:54Z |
| format | Thesis |
| id | ntu-10356/73336 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:21:54Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/733362023-02-28T23:58:20Z Engineering of anti-cancer g-quadruplex nucleic acids and anti-bacterial protein fibers Truong, Thi Hong Anh Phan Anh Tuan School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Functional synthetic biopolymers are widely used in the therapeutic treatment and medical devices. This thesis consists of two parts focusing on nucleic acids and proteins respectively. In the first project, structural conformation and bioactivity of G-quadruplex-forming sequences, derived from a well-known aptamer AGRO100, was explored. Our findings on the novel G-quadruplex structures and their anti-proliferative activity against cancer cells might contribute in the development of oligonucleotides for therapeutic treatment. In the second project, a recombinant protein derived from elastin was synthesized and induced to self-assemble and form a fiber platform for silver nanoparticles formation. The silver-coated protein fibers exhibited the anti-bacterial properties on E. coli and S. aureus. This synthetic protein offers a novel biomaterial for an anti-bacterial coating in medical devices. Doctor of Philosophy (SPMS) 2018-02-13T01:18:20Z 2018-02-13T01:18:20Z 2018 Thesis Truong, T. H. A. (2018). Engineering of anti-cancer g-quadruplex nucleic acids and anti-bacterial protein fibers. Doctoral thesis, Nanyang Technological University, Singapore. http://hdl.handle.net/10356/73336 10.32657/10356/73336 en 122 p. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry Truong, Thi Hong Anh Engineering of anti-cancer g-quadruplex nucleic acids and anti-bacterial protein fibers |
| title | Engineering of anti-cancer g-quadruplex nucleic acids and anti-bacterial protein fibers |
| title_full | Engineering of anti-cancer g-quadruplex nucleic acids and anti-bacterial protein fibers |
| title_fullStr | Engineering of anti-cancer g-quadruplex nucleic acids and anti-bacterial protein fibers |
| title_full_unstemmed | Engineering of anti-cancer g-quadruplex nucleic acids and anti-bacterial protein fibers |
| title_short | Engineering of anti-cancer g-quadruplex nucleic acids and anti-bacterial protein fibers |
| title_sort | engineering of anti cancer g quadruplex nucleic acids and anti bacterial protein fibers |
| topic | DRNTU::Science::Chemistry |
| url | http://hdl.handle.net/10356/73336 |
| work_keys_str_mv | AT truongthihonganh engineeringofanticancergquadruplexnucleicacidsandantibacterialproteinfibers |