Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles
Recently, methods to control the strength of the inter-bead interaction when using DNA G-quadruplexes to link magnetic micro-beads were explored and established. Using those techniques, we propose a method to assess the e ectiveness of G-quadruplex ligands by studying it's e ect on the colloi...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2018
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/74927 |
| _version_ | 1826115590520045568 |
|---|---|
| author | Tan, Keith Wei Rong |
| author2 | Phan Anh Tuan |
| author_facet | Phan Anh Tuan Tan, Keith Wei Rong |
| author_sort | Tan, Keith Wei Rong |
| collection | NTU |
| description | Recently, methods to control the strength of the inter-bead interaction when using DNA G-quadruplexes
to link magnetic micro-beads were explored and established. Using those techniques, we propose a
method to assess the e ectiveness of G-quadruplex ligands by studying it's e ect on the colloidal
interactions of G-quadruplex DNA-coated magnetic micro-particle chains. By adjusting the concentration
of K+ ions in the bu er solution, we select a suitable concentration of the K+ whereby, the natural
dissociation of the magnetic micro-particle chains is optimal. |
| first_indexed | 2024-10-01T03:57:59Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/74927 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:57:59Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/749272023-02-28T23:13:10Z Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles Tan, Keith Wei Rong Phan Anh Tuan School of Physical and Mathematical Sciences DRNTU::Science::Biological sciences::Biophysics Recently, methods to control the strength of the inter-bead interaction when using DNA G-quadruplexes to link magnetic micro-beads were explored and established. Using those techniques, we propose a method to assess the e ectiveness of G-quadruplex ligands by studying it's e ect on the colloidal interactions of G-quadruplex DNA-coated magnetic micro-particle chains. By adjusting the concentration of K+ ions in the bu er solution, we select a suitable concentration of the K+ whereby, the natural dissociation of the magnetic micro-particle chains is optimal. Bachelor of Science in Physics 2018-05-25T01:40:58Z 2018-05-25T01:40:58Z 2018 Final Year Project (FYP) http://hdl.handle.net/10356/74927 en 55 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Biophysics Tan, Keith Wei Rong Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles |
| title | Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles |
| title_full | Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles |
| title_fullStr | Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles |
| title_full_unstemmed | Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles |
| title_short | Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles |
| title_sort | using colloidal disassembly to determine molecular stability of dna coated magnetic micro particles |
| topic | DRNTU::Science::Biological sciences::Biophysics |
| url | http://hdl.handle.net/10356/74927 |
| work_keys_str_mv | AT tankeithweirong usingcolloidaldisassemblytodeterminemolecularstabilityofdnacoatedmagneticmicroparticles |