Optimization of drug release profile for 2D and 3D electrospun fibres for liver fibrosis

The increasing trend of liver-related diseases has resulted in numerous cases of death and is currently highly ranked in terms of deadly diseases. Therefore, more focus has been put on finding a solution for the various type of liver diseases. All liver diseases progress through liver fibrosis de...

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Bibliographic Details
Main Author: Chong, Edwin Yao Zhong
Other Authors: Tan Lay Poh
Format: Final Year Project (FYP)
Language:English
Published: 2019
Subjects:
Online Access:http://hdl.handle.net/10356/76777
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author Chong, Edwin Yao Zhong
author2 Tan Lay Poh
author_facet Tan Lay Poh
Chong, Edwin Yao Zhong
author_sort Chong, Edwin Yao Zhong
collection NTU
description The increasing trend of liver-related diseases has resulted in numerous cases of death and is currently highly ranked in terms of deadly diseases. Therefore, more focus has been put on finding a solution for the various type of liver diseases. All liver diseases progress through liver fibrosis defined by scar tissue formation. With the fast development of health-related researches, many methods have been proposed to overcome the symptoms of liver fibrosis. However, there are many limitations to the present methods. One of the methods that had recently come into the spotlight is the use of electrospinning to fabricate fibre to prepare scaffolds for drug delivery. Our current work investigates the effects of electrospinning on the fabricated fibre and the process of encapsulating Decorin in the electrospun fibre for release study and full encapsulation study. There is also the use of BSA as the protein to optimise the encapsulation percentage within the electrospun fibre. Characterization method like Micro BCA Assay, ELISA Assay, spectrophotometry and scanning electron microscopy (SEM) will be employed.
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spelling ntu-10356/767772023-03-04T15:40:56Z Optimization of drug release profile for 2D and 3D electrospun fibres for liver fibrosis Chong, Edwin Yao Zhong Tan Lay Poh School of Materials Science and Engineering DRNTU::Engineering::Materials The increasing trend of liver-related diseases has resulted in numerous cases of death and is currently highly ranked in terms of deadly diseases. Therefore, more focus has been put on finding a solution for the various type of liver diseases. All liver diseases progress through liver fibrosis defined by scar tissue formation. With the fast development of health-related researches, many methods have been proposed to overcome the symptoms of liver fibrosis. However, there are many limitations to the present methods. One of the methods that had recently come into the spotlight is the use of electrospinning to fabricate fibre to prepare scaffolds for drug delivery. Our current work investigates the effects of electrospinning on the fabricated fibre and the process of encapsulating Decorin in the electrospun fibre for release study and full encapsulation study. There is also the use of BSA as the protein to optimise the encapsulation percentage within the electrospun fibre. Characterization method like Micro BCA Assay, ELISA Assay, spectrophotometry and scanning electron microscopy (SEM) will be employed. Bachelor of Engineering (Materials Engineering) 2019-04-12T03:04:41Z 2019-04-12T03:04:41Z 2019 Final Year Project (FYP) http://hdl.handle.net/10356/76777 en Nanyang Technological University 36 p. application/pdf
spellingShingle DRNTU::Engineering::Materials
Chong, Edwin Yao Zhong
Optimization of drug release profile for 2D and 3D electrospun fibres for liver fibrosis
title Optimization of drug release profile for 2D and 3D electrospun fibres for liver fibrosis
title_full Optimization of drug release profile for 2D and 3D electrospun fibres for liver fibrosis
title_fullStr Optimization of drug release profile for 2D and 3D electrospun fibres for liver fibrosis
title_full_unstemmed Optimization of drug release profile for 2D and 3D electrospun fibres for liver fibrosis
title_short Optimization of drug release profile for 2D and 3D electrospun fibres for liver fibrosis
title_sort optimization of drug release profile for 2d and 3d electrospun fibres for liver fibrosis
topic DRNTU::Engineering::Materials
url http://hdl.handle.net/10356/76777
work_keys_str_mv AT chongedwinyaozhong optimizationofdrugreleaseprofilefor2dand3delectrospunfibresforliverfibrosis