A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction
CD-NP (Cenderitide) is the only chimeric natriuretic peptide that acts on both the A and B natriuretic peptide receptors (NPR). This differential mechanism of action reduces the arterial vasodilating properties, while retaining the cardiac unloading and aldosterone inhibiting actions of the NPR-A re...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2015
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| Online Access: | https://hdl.handle.net/10356/79313 http://hdl.handle.net/10220/38543 |
| _version_ | 1811689447268286464 |
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| author | Martin, Fernando L. Huang, Ying Ying Venkatraman, Subbu Subramanian Burnett, John C. Chen, Horng H. Lim, Soo Ghim Jeson Sangaralingham, S. Ameenuddin, Syed Ng, Xu Wen |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Martin, Fernando L. Huang, Ying Ying Venkatraman, Subbu Subramanian Burnett, John C. Chen, Horng H. Lim, Soo Ghim Jeson Sangaralingham, S. Ameenuddin, Syed Ng, Xu Wen |
| author_sort | Martin, Fernando L. |
| collection | NTU |
| description | CD-NP (Cenderitide) is the only chimeric natriuretic peptide that acts on both the A and B natriuretic peptide receptors (NPR). This differential mechanism of action reduces the arterial vasodilating properties, while retaining the cardiac unloading and aldosterone inhibiting actions of the NPR-A receptor in addition to the direct anti-remodeling actions of the NPR-B receptor. Our objective is to determine the effects of 3 weeks of sustained delivery of CD-NP via a single subcutaneous (SQ) injection of a fully biodegradable in-situ polymer precipitation delivery system (Gel system) in a model of experimental myocardial infarction (MI). |
| first_indexed | 2024-10-01T05:48:15Z |
| format | Journal Article |
| id | ntu-10356/79313 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:48:15Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/793132023-07-14T15:56:49Z A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction Martin, Fernando L. Huang, Ying Ying Venkatraman, Subbu Subramanian Burnett, John C. Chen, Horng H. Lim, Soo Ghim Jeson Sangaralingham, S. Ameenuddin, Syed Ng, Xu Wen School of Materials Science & Engineering CD-NP (Cenderitide) is the only chimeric natriuretic peptide that acts on both the A and B natriuretic peptide receptors (NPR). This differential mechanism of action reduces the arterial vasodilating properties, while retaining the cardiac unloading and aldosterone inhibiting actions of the NPR-A receptor in addition to the direct anti-remodeling actions of the NPR-B receptor. Our objective is to determine the effects of 3 weeks of sustained delivery of CD-NP via a single subcutaneous (SQ) injection of a fully biodegradable in-situ polymer precipitation delivery system (Gel system) in a model of experimental myocardial infarction (MI). Published version 2015-09-01T06:30:24Z 2019-12-06T13:22:19Z 2015-09-01T06:30:24Z 2019-12-06T13:22:19Z 2013 2013 Journal Article Lim, S. G., Jeson Sangaralingham, S., Ameenuddin, S., Martin, F. L., Ng, X. W., Huang, Y. Y., et al. (2013). A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction. BMC Pharmacology and Toxicology, 14, 38-. 2050-6511 https://hdl.handle.net/10356/79313 http://hdl.handle.net/10220/38543 10.1186/2050-6511-14-S1-P38 en BMC pharmacology and toxicology © 2013 Lim et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2 p. application/pdf |
| spellingShingle | Martin, Fernando L. Huang, Ying Ying Venkatraman, Subbu Subramanian Burnett, John C. Chen, Horng H. Lim, Soo Ghim Jeson Sangaralingham, S. Ameenuddin, Syed Ng, Xu Wen A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction |
| title | A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction |
| title_full | A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction |
| title_fullStr | A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction |
| title_full_unstemmed | A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction |
| title_short | A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction |
| title_sort | biodegradable in situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide cd np in an experimental model of myocardial infarction |
| url | https://hdl.handle.net/10356/79313 http://hdl.handle.net/10220/38543 |
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