Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs
Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoy...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/79323 http://hdl.handle.net/10220/16451 |
| _version_ | 1811680205141442560 |
|---|---|
| author | Lee, Wei Li Wee, Peixin Nugraha, Chandra Loo, Say Chye Joachim |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Lee, Wei Li Wee, Peixin Nugraha, Chandra Loo, Say Chye Joachim |
| author_sort | Lee, Wei Li |
| collection | NTU |
| description | Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system. |
| first_indexed | 2024-10-01T03:21:21Z |
| format | Journal Article |
| id | ntu-10356/79323 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:21:21Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/793232023-07-14T15:49:30Z Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs Lee, Wei Li Wee, Peixin Nugraha, Chandra Loo, Say Chye Joachim School of Materials Science & Engineering DRNTU::Engineering::Materials::Biomaterials Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system. ASTAR (Agency for Sci., Tech. and Research, S’pore) Published Version 2013-10-10T09:25:51Z 2019-12-06T13:22:33Z 2013-10-10T09:25:51Z 2019-12-06T13:22:33Z 2013 2013 Journal Article Lee, W. L., Wee, P., Nugraha, C., & Loo, S. C. J. (2013). Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs. Journal of Materials Chemistry B, 1(8), 1090-1095. https://hdl.handle.net/10356/79323 http://hdl.handle.net/10220/16451 10.1039/c2tb00495j en Journal of materials chemistry B © 2013 Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. application/pdf |
| spellingShingle | DRNTU::Engineering::Materials::Biomaterials Lee, Wei Li Wee, Peixin Nugraha, Chandra Loo, Say Chye Joachim Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs |
| title | Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs |
| title_full | Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs |
| title_fullStr | Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs |
| title_full_unstemmed | Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs |
| title_short | Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs |
| title_sort | gastric floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs |
| topic | DRNTU::Engineering::Materials::Biomaterials |
| url | https://hdl.handle.net/10356/79323 http://hdl.handle.net/10220/16451 |
| work_keys_str_mv | AT leeweili gastricfloatingmicrocapsulesprovidecontrolledandsustainedreleaseofmultiplecardiovasculardrugs AT weepeixin gastricfloatingmicrocapsulesprovidecontrolledandsustainedreleaseofmultiplecardiovasculardrugs AT nugrahachandra gastricfloatingmicrocapsulesprovidecontrolledandsustainedreleaseofmultiplecardiovasculardrugs AT loosaychyejoachim gastricfloatingmicrocapsulesprovidecontrolledandsustainedreleaseofmultiplecardiovasculardrugs |