Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs
An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor...
| Κύριοι συγγραφείς: | , , , |
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| Άλλοι συγγραφείς: | |
| Μορφή: | Journal Article |
| Γλώσσα: | English |
| Έκδοση: |
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://hdl.handle.net/10356/79354 http://hdl.handle.net/10220/25021 |
| _version_ | 1826126046132436992 |
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| author | Koh, P.-F. Wang, P. Huang, J.-M. Loh, T.-P. |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Koh, P.-F. Wang, P. Huang, J.-M. Loh, T.-P. |
| author_sort | Koh, P.-F. |
| collection | NTU |
| description | An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist. |
| first_indexed | 2024-10-01T06:46:19Z |
| format | Journal Article |
| id | ntu-10356/79354 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:46:19Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/793542023-02-28T19:29:49Z Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs Koh, P.-F. Wang, P. Huang, J.-M. Loh, T.-P. School of Physical and Mathematical Sciences DRNTU::Science::Chemistry An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist. Published version 2015-02-06T02:42:51Z 2019-12-06T13:23:16Z 2015-02-06T02:42:51Z 2019-12-06T13:23:16Z 2014 2014 Journal Article Koh, P.-F., Wang, P., Huang, J.-M., & Loh, T.-P. (2014). Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs. Chemical communications, 50(61), 8324-8327. 1359-7345 https://hdl.handle.net/10356/79354 http://hdl.handle.net/10220/25021 10.1039/C4CC02645D en Chemical communications © 2014 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry Koh, P.-F. Wang, P. Huang, J.-M. Loh, T.-P. Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs |
| title | Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs |
| title_full | Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs |
| title_fullStr | Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs |
| title_full_unstemmed | Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs |
| title_short | Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs |
| title_sort | biomass derived furfural based facile synthesis of protected 2s phenyl 3 piperidone a common intermediate for many drugs |
| topic | DRNTU::Science::Chemistry |
| url | https://hdl.handle.net/10356/79354 http://hdl.handle.net/10220/25021 |
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