Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs

An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor...

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Hlavní autoři: Koh, P.-F., Wang, P., Huang, J.-M., Loh, T.-P.
Další autoři: School of Physical and Mathematical Sciences
Médium: Journal Article
Jazyk:English
Vydáno: 2015
Témata:
On-line přístup:https://hdl.handle.net/10356/79354
http://hdl.handle.net/10220/25021