Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines
Facile access to trisubstituted pyridines from α-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts mak...
| Main Authors: | , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2014
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/79664 http://hdl.handle.net/10220/23927 |
| _version_ | 1811691488530137088 |
|---|---|
| author | Chi, Robin Yonggui Hao, Lin Chen, Xingkuan Chen, Shaojin Jiang, Ke Torres, Jaume |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Chi, Robin Yonggui Hao, Lin Chen, Xingkuan Chen, Shaojin Jiang, Ke Torres, Jaume |
| author_sort | Chi, Robin Yonggui |
| collection | NTU |
| description | Facile access to trisubstituted pyridines from α-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts make this method very attractive. |
| first_indexed | 2024-10-01T06:20:41Z |
| format | Journal Article |
| id | ntu-10356/79664 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:20:41Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/796642023-02-28T16:58:08Z Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines Chi, Robin Yonggui Hao, Lin Chen, Xingkuan Chen, Shaojin Jiang, Ke Torres, Jaume School of Physical and Mathematical Sciences School of Biological Sciences DRNTU::Science::Biological sciences Facile access to trisubstituted pyridines from α-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts make this method very attractive. 2014-10-01T02:09:37Z 2019-12-06T13:30:25Z 2014-10-01T02:09:37Z 2019-12-06T13:30:25Z 2014 2014 Journal Article Hao, L., Chen, X., Chen, S., Jiang, K., Torres, J., & Chi, Y. R. (2014). Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines. Organic chemistry frontiers, 1(2), 148-150. https://hdl.handle.net/10356/79664 http://hdl.handle.net/10220/23927 10.1039/C3QO00045A 179797 en Organic chemistry frontiers © 2014 the Partner Organisations. 3 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences Chi, Robin Yonggui Hao, Lin Chen, Xingkuan Chen, Shaojin Jiang, Ke Torres, Jaume Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines |
| title | Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines |
| title_full | Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines |
| title_fullStr | Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines |
| title_full_unstemmed | Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines |
| title_short | Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines |
| title_sort | access to pyridines via dmap catalyzed activation of α chloro acetic ester to react with unsaturated imines |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/79664 http://hdl.handle.net/10220/23927 |
| work_keys_str_mv | AT chirobinyonggui accesstopyridinesviadmapcatalyzedactivationofachloroaceticestertoreactwithunsaturatedimines AT haolin accesstopyridinesviadmapcatalyzedactivationofachloroaceticestertoreactwithunsaturatedimines AT chenxingkuan accesstopyridinesviadmapcatalyzedactivationofachloroaceticestertoreactwithunsaturatedimines AT chenshaojin accesstopyridinesviadmapcatalyzedactivationofachloroaceticestertoreactwithunsaturatedimines AT jiangke accesstopyridinesviadmapcatalyzedactivationofachloroaceticestertoreactwithunsaturatedimines AT torresjaume accesstopyridinesviadmapcatalyzedactivationofachloroaceticestertoreactwithunsaturatedimines |