Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles
Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coher...
| Main Authors: | , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2016
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/80244 http://hdl.handle.net/10220/40456 |
| _version_ | 1811685885060579328 |
|---|---|
| author | Shi, Wei Liu, Xinyu Wei, Chao Xu, Zhichuan J. Sim, Stanley Siong Wei Liu, Linbo Xu, Chenjie |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Shi, Wei Liu, Xinyu Wei, Chao Xu, Zhichuan J. Sim, Stanley Siong Wei Liu, Linbo Xu, Chenjie |
| author_sort | Shi, Wei |
| collection | NTU |
| description | Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT. |
| first_indexed | 2024-10-01T04:51:37Z |
| format | Journal Article |
| id | ntu-10356/80244 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:51:37Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/802442020-06-01T10:13:56Z Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles Shi, Wei Liu, Xinyu Wei, Chao Xu, Zhichuan J. Sim, Stanley Siong Wei Liu, Linbo Xu, Chenjie School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering School of Materials Science & Engineering Heterogeneous nanoparticles Magnetofection Gene delivery Dumbbell nanoparticles Micro-optical coherence tomography Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT. NMRC (Natl Medical Research Council, S’pore) Accepted version 2016-04-15T07:08:09Z 2019-12-06T13:45:43Z 2016-04-15T07:08:09Z 2019-12-06T13:45:43Z 2015 Journal Article Shi, W., Liu, X., Wei, C., Xu, Z. J., Sim, S. S. W., Liu, L., et al. (2015). Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles. Nanoscale, 7(41), 17249-17253. 2040-3364 https://hdl.handle.net/10356/80244 http://hdl.handle.net/10220/40456 10.1039/C5NR05459A en Nanoscale © 2016 Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Nanoscale, Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C5NR05459A]. 11 p. application/pdf |
| spellingShingle | Heterogeneous nanoparticles Magnetofection Gene delivery Dumbbell nanoparticles Micro-optical coherence tomography Shi, Wei Liu, Xinyu Wei, Chao Xu, Zhichuan J. Sim, Stanley Siong Wei Liu, Linbo Xu, Chenjie Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles |
| title | Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles |
| title_full | Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles |
| title_fullStr | Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles |
| title_full_unstemmed | Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles |
| title_short | Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles |
| title_sort | micro optical coherence tomography tracking of magnetic gene transfection via au fe3o4 dumbbell nanoparticles |
| topic | Heterogeneous nanoparticles Magnetofection Gene delivery Dumbbell nanoparticles Micro-optical coherence tomography |
| url | https://hdl.handle.net/10356/80244 http://hdl.handle.net/10220/40456 |
| work_keys_str_mv | AT shiwei microopticalcoherencetomographytrackingofmagneticgenetransfectionviaaufe3o4dumbbellnanoparticles AT liuxinyu microopticalcoherencetomographytrackingofmagneticgenetransfectionviaaufe3o4dumbbellnanoparticles AT weichao microopticalcoherencetomographytrackingofmagneticgenetransfectionviaaufe3o4dumbbellnanoparticles AT xuzhichuanj microopticalcoherencetomographytrackingofmagneticgenetransfectionviaaufe3o4dumbbellnanoparticles AT simstanleysiongwei microopticalcoherencetomographytrackingofmagneticgenetransfectionviaaufe3o4dumbbellnanoparticles AT liulinbo microopticalcoherencetomographytrackingofmagneticgenetransfectionviaaufe3o4dumbbellnanoparticles AT xuchenjie microopticalcoherencetomographytrackingofmagneticgenetransfectionviaaufe3o4dumbbellnanoparticles |