Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly
Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but o...
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| Format: | Journal Article |
| Language: | English |
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2017
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| Online Access: | https://hdl.handle.net/10356/80334 http://hdl.handle.net/10220/42134 |
| _version_ | 1826122796335366144 |
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| author | Wood, Will Martin, Paul |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Wood, Will Martin, Paul |
| author_sort | Wood, Will |
| collection | NTU |
| description | Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response. |
| first_indexed | 2024-10-01T05:54:22Z |
| format | Journal Article |
| id | ntu-10356/80334 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:54:22Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/803342020-11-01T05:22:12Z Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly Wood, Will Martin, Paul Lee Kong Chian School of Medicine (LKCMedicine) Drosophila Macrophage Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response. Published version 2017-02-28T06:41:42Z 2019-12-06T13:47:25Z 2017-02-28T06:41:42Z 2019-12-06T13:47:25Z 2017 Journal Article Wood, W., & Martin, P. (2017). Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly. Developmental Cell, 40(3), 221-233. 1534-5807 https://hdl.handle.net/10356/80334 http://hdl.handle.net/10220/42134 10.1016/j.devcel.2017.01.001 en Developmental Cell © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). 13 p. application/pdf |
| spellingShingle | Drosophila Macrophage Wood, Will Martin, Paul Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly |
| title | Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly |
| title_full | Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly |
| title_fullStr | Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly |
| title_full_unstemmed | Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly |
| title_short | Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly |
| title_sort | macrophage functions in tissue patterning and disease new insights from the fly |
| topic | Drosophila Macrophage |
| url | https://hdl.handle.net/10356/80334 http://hdl.handle.net/10220/42134 |
| work_keys_str_mv | AT woodwill macrophagefunctionsintissuepatterninganddiseasenewinsightsfromthefly AT martinpaul macrophagefunctionsintissuepatterninganddiseasenewinsightsfromthefly |