Combined optical and acoustic resolution photoacoustic microscopy
Photoacoustic imaging is a fast growing in vivo imaging modality combining the optical absorption contrast and high spatial ultrasonic resolution. Using this technique deeper tissue penetration greater than optical mean free path (~1 mm in skin) is possible. Low resolution with deep penetration dept...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Conference Paper |
| Language: | English |
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2017
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| Online Access: | https://hdl.handle.net/10356/80361 http://hdl.handle.net/10220/42152 |
| _version_ | 1826127013052678144 |
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| author | Moothanchery, Mohesh Pramanik, Manojit |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Moothanchery, Mohesh Pramanik, Manojit |
| author_sort | Moothanchery, Mohesh |
| collection | NTU |
| description | Photoacoustic imaging is a fast growing in vivo imaging modality combining the optical absorption contrast and high spatial ultrasonic resolution. Using this technique deeper tissue penetration greater than optical mean free path (~1 mm in skin) is possible. Low resolution with deep penetration depth is possible utilizing acoustic focusing and high resolution with shallow imaging depth can be possible by optical focusing using different photoacoustic microscopy (PAM) systems. Here, we present a combined/switchable optical resolution and acoustic resolution photoacoustic microscopy (OR-AR-PAM) system capable of both high resolution and low resolution deep tissue imaging on the same sample. Lateral resolution of 3.9 μm using optical focusing and lateral resolution of 57 μm using acoustic focusing was successfully demonstrated using the combined system. |
| first_indexed | 2024-10-01T07:01:47Z |
| format | Conference Paper |
| id | ntu-10356/80361 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:01:47Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/803612023-12-29T06:44:13Z Combined optical and acoustic resolution photoacoustic microscopy Moothanchery, Mohesh Pramanik, Manojit School of Chemical and Biomedical Engineering Proceeding of SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017 Photoacoustic Imaging Optical resolution photoacoustic microscopy Photoacoustic imaging is a fast growing in vivo imaging modality combining the optical absorption contrast and high spatial ultrasonic resolution. Using this technique deeper tissue penetration greater than optical mean free path (~1 mm in skin) is possible. Low resolution with deep penetration depth is possible utilizing acoustic focusing and high resolution with shallow imaging depth can be possible by optical focusing using different photoacoustic microscopy (PAM) systems. Here, we present a combined/switchable optical resolution and acoustic resolution photoacoustic microscopy (OR-AR-PAM) system capable of both high resolution and low resolution deep tissue imaging on the same sample. Lateral resolution of 3.9 μm using optical focusing and lateral resolution of 57 μm using acoustic focusing was successfully demonstrated using the combined system. MOE (Min. of Education, S’pore) Published version 2017-03-06T03:15:02Z 2019-12-06T13:47:58Z 2017-03-06T03:15:02Z 2019-12-06T13:47:58Z 2017-03-01 2017 Conference Paper Moothanchery, M., & Pramanik, M. (2017). Combined optical and acoustic resolution photoacoustic microscopy. Proceeding of SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100644P-. https://hdl.handle.net/10356/80361 http://hdl.handle.net/10220/42152 10.1117/12.2251258 196224 en © 2017 Society of Photo-optical Instrumentation Engineers (SPIE). This paper was published in Proceeding of SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017 and is made available as an electronic reprint (preprint) with permission of SPIE. The published version is available at: http://dx.doi.org/10.1117/12.2251258. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 6 p. application/pdf |
| spellingShingle | Photoacoustic Imaging Optical resolution photoacoustic microscopy Moothanchery, Mohesh Pramanik, Manojit Combined optical and acoustic resolution photoacoustic microscopy |
| title | Combined optical and acoustic resolution photoacoustic microscopy |
| title_full | Combined optical and acoustic resolution photoacoustic microscopy |
| title_fullStr | Combined optical and acoustic resolution photoacoustic microscopy |
| title_full_unstemmed | Combined optical and acoustic resolution photoacoustic microscopy |
| title_short | Combined optical and acoustic resolution photoacoustic microscopy |
| title_sort | combined optical and acoustic resolution photoacoustic microscopy |
| topic | Photoacoustic Imaging Optical resolution photoacoustic microscopy |
| url | https://hdl.handle.net/10356/80361 http://hdl.handle.net/10220/42152 |
| work_keys_str_mv | AT moothancherymohesh combinedopticalandacousticresolutionphotoacousticmicroscopy AT pramanikmanojit combinedopticalandacousticresolutionphotoacousticmicroscopy |