Sustained delivery of siRNA/mesoporous silica nanoparticle complexes from nanofiber scaffolds for long-term gene silencing

Sustained delivery of siRNA/mesoporous silica nanoparticle complexes from nanofiber scaffolds for long-term gene silencing

A low toxicity and efficient delivery system is needed to deliver small interfering RNAs (siRNA) in vitro and in vivo. The use of mesoporous silica nanoparticles (MSN) is becoming increasingly common due to its biocompatibility, tunable pore size and customizable properties. However, bolus delivery...

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Bibliographic Details
Main Authors: Pinese, Coline, Lin, Junquan, Milbreta, Ulla, Li, Mingqiang, Wang, Yucai, Leong, Kam W., Chew, Sing Yian
Other Authors: School of Chemical and Biomedical Engineering
Format: Journal Article
Language:English
Published: 2018
Subjects:
Gene Silencing
DRNTU::Science::Medicine::Biomedical engineering
Electrospinning
Online Access:https://hdl.handle.net/10356/80400
http://hdl.handle.net/10220/46518

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