Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging
Despite the deeper tissue penetration of photoacoustic (PA) imaging, its sensitivity is generally lower than optical imaging. This fact partially restricts the applications of PA imaging and greatly stimulates the development of sensitive PA imaging agents. We herein report that the surface coating...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2017
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| Online Access: | https://hdl.handle.net/10356/80510 http://hdl.handle.net/10220/42155 |
| _version_ | 1826118535384924160 |
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| author | Zhen, Xu Feng, Xiaohua Xie, Chen Zheng, Yuanjin Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Zhen, Xu Feng, Xiaohua Xie, Chen Zheng, Yuanjin Pu, Kanyi |
| author_sort | Zhen, Xu |
| collection | NTU |
| description | Despite the deeper tissue penetration of photoacoustic (PA) imaging, its sensitivity is generally lower than optical imaging. This fact partially restricts the applications of PA imaging and greatly stimulates the development of sensitive PA imaging agents. We herein report that the surface coating of semiconducting polymer nanoparticles (SPNs) with the silica layer can simultaneously amplify fluorescence and PA brightness while maintaining their photothermal conversion efficiency nearly unchanged. As compared with the bare SPNs, the silica-coated SPNs (SPNs-SiO2) have higher photothermal heating rate in the initial stage of laser irradiation due to the higher interfacial thermal conductance between the silica layer and water relative to that between the SP and water. Such an interfacial effect consequently results in sharp temperature increase and in turn amplified PA brightness for SPNs-SiO2. By conjugating poly(ethylene glycol) (PEG) and cyclic-RGD onto SPNs-SiO2, targeted PA imaging of tumor in living mice is demonstrated after systemic administration, showing a high signal to background ratio. Our study provides a surface engineering approach to amplify the PA signals of organic nanoparticles for molecular imaging. |
| first_indexed | 2024-10-01T04:45:01Z |
| format | Journal Article |
| id | ntu-10356/80510 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:45:01Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/805102020-03-07T11:35:20Z Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging Zhen, Xu Feng, Xiaohua Xie, Chen Zheng, Yuanjin Pu, Kanyi School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering Semiconducting polymer nanoparticles Photoacoustic imaging Despite the deeper tissue penetration of photoacoustic (PA) imaging, its sensitivity is generally lower than optical imaging. This fact partially restricts the applications of PA imaging and greatly stimulates the development of sensitive PA imaging agents. We herein report that the surface coating of semiconducting polymer nanoparticles (SPNs) with the silica layer can simultaneously amplify fluorescence and PA brightness while maintaining their photothermal conversion efficiency nearly unchanged. As compared with the bare SPNs, the silica-coated SPNs (SPNs-SiO2) have higher photothermal heating rate in the initial stage of laser irradiation due to the higher interfacial thermal conductance between the silica layer and water relative to that between the SP and water. Such an interfacial effect consequently results in sharp temperature increase and in turn amplified PA brightness for SPNs-SiO2. By conjugating poly(ethylene glycol) (PEG) and cyclic-RGD onto SPNs-SiO2, targeted PA imaging of tumor in living mice is demonstrated after systemic administration, showing a high signal to background ratio. Our study provides a surface engineering approach to amplify the PA signals of organic nanoparticles for molecular imaging. MOE (Min. of Education, S’pore) Accepted version 2017-03-13T03:55:35Z 2019-12-06T13:51:09Z 2017-03-13T03:55:35Z 2019-12-06T13:51:09Z 2017 2017 Journal Article Zhen, X., Feng, X., Xie, C., Zheng, Y., & Pu, K. (2017). Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging. Biomaterials, 127, 97-106. 0142-9612 https://hdl.handle.net/10356/80510 http://hdl.handle.net/10220/42155 10.1016/j.biomaterials.2017.03.003 196285 en Biomaterials © 2017 Elsevier Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomaterials, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.biomaterials.2017.03.003]. 30 p. application/pdf |
| spellingShingle | Semiconducting polymer nanoparticles Photoacoustic imaging Zhen, Xu Feng, Xiaohua Xie, Chen Zheng, Yuanjin Pu, Kanyi Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging |
| title | Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging |
| title_full | Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging |
| title_fullStr | Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging |
| title_full_unstemmed | Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging |
| title_short | Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging |
| title_sort | surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging |
| topic | Semiconducting polymer nanoparticles Photoacoustic imaging |
| url | https://hdl.handle.net/10356/80510 http://hdl.handle.net/10220/42155 |
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