Tunable Chemical Release from Polyester Thin Film by Photocatalytic Zinc Oxide and Doped LiYF4 Upconverting Nanoparticles
Once manufactured or implanted, polyester release kinetics tend to be fixed with little modulation possible for optimal local chemical concentrations. Here, a typical implantable polyester was fabricated into thin films (∼50 μm thick) with additives of photocatalytic ZnO nanoparticles, lanthanide-do...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/80577 http://hdl.handle.net/10220/42169 |
| _version_ | 1811684359612137472 |
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| author | Cheng, Ting Ortiz, Raphael Francois Vedantham, Kumar Naccache, Rafik Vetrone, Fiorenzo Marks, Robert S. Steele, Terry W. J. |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Cheng, Ting Ortiz, Raphael Francois Vedantham, Kumar Naccache, Rafik Vetrone, Fiorenzo Marks, Robert S. Steele, Terry W. J. |
| author_sort | Cheng, Ting |
| collection | NTU |
| description | Once manufactured or implanted, polyester release kinetics tend to be fixed with little modulation possible for optimal local chemical concentrations. Here, a typical implantable polyester was fabricated into thin films (∼50 μm thick) with additives of photocatalytic ZnO nanoparticles, lanthanide-doped LiYF4 nanoparticle upconverting nanoparticles, or a combination thereof and irradiated with either 6 mW ultraviolet (365 nm) light emitting diodes or 50 mW near-infrared (980 nm) laser diodes to induce polymer photooxidation. Irradiated polyester films with the aforementioned photoadditives had enhanced release kinetics up to 30 times more than nonirradiated, neat films with extended release times of 28 days. Near-infrared, ZnO-mediated photocatalysis had the highest light on/light off ratio release kinetics of 15.4, while doped LiYF4 upconversion nanoparticles paired with ZnO nanoparticles had the highest linear R2 correlation of 0.98 with respect to duty cycle and release kinetics. Future applications of the technology will aim toward modulation of previously developed polymeric reagents/drugs for real-time, feedback-optimized release. |
| first_indexed | 2024-10-01T04:27:23Z |
| format | Journal Article |
| id | ntu-10356/80577 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:27:23Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/805772023-07-14T15:49:32Z Tunable Chemical Release from Polyester Thin Film by Photocatalytic Zinc Oxide and Doped LiYF4 Upconverting Nanoparticles Cheng, Ting Ortiz, Raphael Francois Vedantham, Kumar Naccache, Rafik Vetrone, Fiorenzo Marks, Robert S. Steele, Terry W. J. School of Materials Science & Engineering PLGA Photocatalysis Once manufactured or implanted, polyester release kinetics tend to be fixed with little modulation possible for optimal local chemical concentrations. Here, a typical implantable polyester was fabricated into thin films (∼50 μm thick) with additives of photocatalytic ZnO nanoparticles, lanthanide-doped LiYF4 nanoparticle upconverting nanoparticles, or a combination thereof and irradiated with either 6 mW ultraviolet (365 nm) light emitting diodes or 50 mW near-infrared (980 nm) laser diodes to induce polymer photooxidation. Irradiated polyester films with the aforementioned photoadditives had enhanced release kinetics up to 30 times more than nonirradiated, neat films with extended release times of 28 days. Near-infrared, ZnO-mediated photocatalysis had the highest light on/light off ratio release kinetics of 15.4, while doped LiYF4 upconversion nanoparticles paired with ZnO nanoparticles had the highest linear R2 correlation of 0.98 with respect to duty cycle and release kinetics. Future applications of the technology will aim toward modulation of previously developed polymeric reagents/drugs for real-time, feedback-optimized release. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Accepted version 2017-03-16T03:13:16Z 2019-12-06T13:52:33Z 2017-03-16T03:13:16Z 2019-12-06T13:52:33Z 2014 Journal Article Cheng, T., Ortiz, R. F., Vedantham, K., Naccache, R., Vetrone, F., Marks, R. S., et al. (2015). Tunable Chemical Release from Polyester Thin Film by Photocatalytic Zinc Oxide and Doped LiYF4 Upconverting Nanoparticles. Biomacromolecules, 16(1), 364-373. 1525-7797 https://hdl.handle.net/10356/80577 http://hdl.handle.net/10220/42169 10.1021/bm501567m en Biomacromolecules © 2014 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomacromolecules, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/bm501567m]. 37 p. application/pdf |
| spellingShingle | PLGA Photocatalysis Cheng, Ting Ortiz, Raphael Francois Vedantham, Kumar Naccache, Rafik Vetrone, Fiorenzo Marks, Robert S. Steele, Terry W. J. Tunable Chemical Release from Polyester Thin Film by Photocatalytic Zinc Oxide and Doped LiYF4 Upconverting Nanoparticles |
| title | Tunable Chemical Release from Polyester Thin Film by Photocatalytic Zinc Oxide and Doped LiYF4 Upconverting Nanoparticles |
| title_full | Tunable Chemical Release from Polyester Thin Film by Photocatalytic Zinc Oxide and Doped LiYF4 Upconverting Nanoparticles |
| title_fullStr | Tunable Chemical Release from Polyester Thin Film by Photocatalytic Zinc Oxide and Doped LiYF4 Upconverting Nanoparticles |
| title_full_unstemmed | Tunable Chemical Release from Polyester Thin Film by Photocatalytic Zinc Oxide and Doped LiYF4 Upconverting Nanoparticles |
| title_short | Tunable Chemical Release from Polyester Thin Film by Photocatalytic Zinc Oxide and Doped LiYF4 Upconverting Nanoparticles |
| title_sort | tunable chemical release from polyester thin film by photocatalytic zinc oxide and doped liyf4 upconverting nanoparticles |
| topic | PLGA Photocatalysis |
| url | https://hdl.handle.net/10356/80577 http://hdl.handle.net/10220/42169 |
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