Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment
Plasma treatments are investigated as a post-production method of tuning drug release and bioadhesion of poly(lactic-co-glycolic acid) (PLGA) thin films. PLGA films were treated under varying conditions by controlling gas flow rate, composition, treatment time, and radio frequency (RF) power. In vit...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2017
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| Online Access: | https://hdl.handle.net/10356/80581 http://hdl.handle.net/10220/42168 |
| _version_ | 1811678128235347968 |
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| author | Mogal, Vishal T. Yin, Chaw Su O’Rorke, Richard Boujday, Souhir Méthivier, Christophe Venkatraman, Subbu S. Steele, Terry W. J. |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Mogal, Vishal T. Yin, Chaw Su O’Rorke, Richard Boujday, Souhir Méthivier, Christophe Venkatraman, Subbu S. Steele, Terry W. J. |
| author_sort | Mogal, Vishal T. |
| collection | NTU |
| description | Plasma treatments are investigated as a post-production method of tuning drug release and bioadhesion of poly(lactic-co-glycolic acid) (PLGA) thin films. PLGA films were treated under varying conditions by controlling gas flow rate, composition, treatment time, and radio frequency (RF) power. In vitro release of the drug-like molecule fluorescein diacetate (FDAc) from plasma-treated PLGA was tunable by controlling RF power; an increase of 65% cumulative release is reported compared to controls. Bioadhesion was sensitive to RF power and treatment time, assessed using ex vivo shear–stress tests with wetted swine aorta. We report a maximum bioadhesion ∼6-fold that of controls and 5-fold that of DOPA-based mussel adhesives tested to swine skin.1 The novelty of this post-treatment is the activation of a hydrophobic polyester film for bioadhesion, which can be quenched, while simultaneously tuning drug-release kinetics. This exemplifies the promise of plasma post-treatment for in-clinic bioadhesive activation, along with technological advancements, i.e., atmospheric plasma and hand-held “plasma pencils”. |
| first_indexed | 2024-10-01T02:48:20Z |
| format | Journal Article |
| id | ntu-10356/80581 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:48:20Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/805812023-07-14T15:46:56Z Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment Mogal, Vishal T. Yin, Chaw Su O’Rorke, Richard Boujday, Souhir Méthivier, Christophe Venkatraman, Subbu S. Steele, Terry W. J. School of Materials Science & Engineering Radicals Bioadhesion Plasma treatments are investigated as a post-production method of tuning drug release and bioadhesion of poly(lactic-co-glycolic acid) (PLGA) thin films. PLGA films were treated under varying conditions by controlling gas flow rate, composition, treatment time, and radio frequency (RF) power. In vitro release of the drug-like molecule fluorescein diacetate (FDAc) from plasma-treated PLGA was tunable by controlling RF power; an increase of 65% cumulative release is reported compared to controls. Bioadhesion was sensitive to RF power and treatment time, assessed using ex vivo shear–stress tests with wetted swine aorta. We report a maximum bioadhesion ∼6-fold that of controls and 5-fold that of DOPA-based mussel adhesives tested to swine skin.1 The novelty of this post-treatment is the activation of a hydrophobic polyester film for bioadhesion, which can be quenched, while simultaneously tuning drug-release kinetics. This exemplifies the promise of plasma post-treatment for in-clinic bioadhesive activation, along with technological advancements, i.e., atmospheric plasma and hand-held “plasma pencils”. MOE (Min. of Education, S’pore) Accepted version 2017-03-16T03:01:20Z 2019-12-06T13:52:37Z 2017-03-16T03:01:20Z 2019-12-06T13:52:37Z 2014 Journal Article Mogal, V. T., Yin, C. S., O’Rorke, R., Boujday, S., Méthivier, C., Venkatraman, S. S., et al. (2014). Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment. ACS Applied Materials & Interfaces, 6(8), 5749-5758. 1944-8244 https://hdl.handle.net/10356/80581 http://hdl.handle.net/10220/42168 10.1021/am500454b en ACS Applied Materials & Interfaces © 2014 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by ACS Applied Materials & Interfaces, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/am500454b]. 42 p. application/pdf |
| spellingShingle | Radicals Bioadhesion Mogal, Vishal T. Yin, Chaw Su O’Rorke, Richard Boujday, Souhir Méthivier, Christophe Venkatraman, Subbu S. Steele, Terry W. J. Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment |
| title | Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment |
| title_full | Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment |
| title_fullStr | Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment |
| title_full_unstemmed | Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment |
| title_short | Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment |
| title_sort | tuning model drug release and soft tissue bioadhesion of polyester films by plasma post treatment |
| topic | Radicals Bioadhesion |
| url | https://hdl.handle.net/10356/80581 http://hdl.handle.net/10220/42168 |
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