Addressing Unmet Clinical Needs with UV Bioadhesives
The invasive practice of suturing for wound closure has persisted for millennia; with the rate of medical development, it is staggering that there are few viable alternatives to invasive mechanical fasteners. Biocompatible and biodegradable polymers are attractive candidates for versatile bioadhesiv...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2017
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| Online Access: | https://hdl.handle.net/10356/80584 http://hdl.handle.net/10220/42167 |
| _version_ | 1824453205735505920 |
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| author | O’Rorke, Richard D. Pokholenko, Oleksandr Gao, Feng Cheng, Ting Shah, Ankur Mogal, Vishal Steele, Terry W. J. |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering O’Rorke, Richard D. Pokholenko, Oleksandr Gao, Feng Cheng, Ting Shah, Ankur Mogal, Vishal Steele, Terry W. J. |
| author_sort | O’Rorke, Richard D. |
| collection | NTU |
| description | The invasive practice of suturing for wound closure has persisted for millennia; with the rate of medical development, it is staggering that there are few viable alternatives to invasive mechanical fasteners. Biocompatible and biodegradable polymers are attractive candidates for versatile bioadhesives and could revolutionize surgical procedures. Bioadhesives can be broadly placed into two groups: activated and instant. Almost all commercially available bioadhesives are instant, which cross-link by mixing two components or on contact with moisture. Activated bioadhesives, on the other hand, allow control of when and where a bioadhesive cross-links and, in some cases, the extent of cross-linking. Despite significant progress, there has been little translation of activated bioadhesives to clinical use. This review discusses recent developments in UV-activated bioadhesives toward addressing unmet clinical needs. |
| first_indexed | 2024-10-01T07:57:02Z |
| format | Journal Article |
| id | ntu-10356/80584 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:57:02Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/805842023-07-14T15:49:34Z Addressing Unmet Clinical Needs with UV Bioadhesives O’Rorke, Richard D. Pokholenko, Oleksandr Gao, Feng Cheng, Ting Shah, Ankur Mogal, Vishal Steele, Terry W. J. School of Materials Science & Engineering Unmet clinical applications UV-activated bioadhesives The invasive practice of suturing for wound closure has persisted for millennia; with the rate of medical development, it is staggering that there are few viable alternatives to invasive mechanical fasteners. Biocompatible and biodegradable polymers are attractive candidates for versatile bioadhesives and could revolutionize surgical procedures. Bioadhesives can be broadly placed into two groups: activated and instant. Almost all commercially available bioadhesives are instant, which cross-link by mixing two components or on contact with moisture. Activated bioadhesives, on the other hand, allow control of when and where a bioadhesive cross-links and, in some cases, the extent of cross-linking. Despite significant progress, there has been little translation of activated bioadhesives to clinical use. This review discusses recent developments in UV-activated bioadhesives toward addressing unmet clinical needs. MOE (Min. of Education, S’pore) Published version 2017-03-16T02:34:36Z 2019-12-06T13:52:41Z 2017-03-16T02:34:36Z 2019-12-06T13:52:41Z 2017 Journal Article O’Rorke, R. D., Pokholenko, O., Gao, F., Cheng, T., Shah, A., Mogal, V., et al. (2017). Addressing Unmet Clinical Needs with UV Bioadhesives. Biomacromolecules, 18(3), 674-682. 1525-7797 https://hdl.handle.net/10356/80584 http://hdl.handle.net/10220/42167 10.1021/acs.biomac.6b01743 en Biomacromolecules This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. 9 p. application/pdf |
| spellingShingle | Unmet clinical applications UV-activated bioadhesives O’Rorke, Richard D. Pokholenko, Oleksandr Gao, Feng Cheng, Ting Shah, Ankur Mogal, Vishal Steele, Terry W. J. Addressing Unmet Clinical Needs with UV Bioadhesives |
| title | Addressing Unmet Clinical Needs with UV Bioadhesives |
| title_full | Addressing Unmet Clinical Needs with UV Bioadhesives |
| title_fullStr | Addressing Unmet Clinical Needs with UV Bioadhesives |
| title_full_unstemmed | Addressing Unmet Clinical Needs with UV Bioadhesives |
| title_short | Addressing Unmet Clinical Needs with UV Bioadhesives |
| title_sort | addressing unmet clinical needs with uv bioadhesives |
| topic | Unmet clinical applications UV-activated bioadhesives |
| url | https://hdl.handle.net/10356/80584 http://hdl.handle.net/10220/42167 |
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