Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma
Nanoparticles (NPs) have great potential as drug delivery systems or as drugs for treating certain diseases. We designed three NPs with different charges and modifications with PEG to treat tumors. PDLA-CS, PEG-PLGA-PLL, and PEG-PS/CaP NPs were designed and evaluated to assess NPs fate in vivo and e...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/10356/80669 http://hdl.handle.net/10220/40625 |
| _version_ | 1826127374444396544 |
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| author | Wang, Qi Sun, Ying Zhang, Zhirong Duan, Yourong |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Wang, Qi Sun, Ying Zhang, Zhirong Duan, Yourong |
| author_sort | Wang, Qi |
| collection | NTU |
| description | Nanoparticles (NPs) have great potential as drug delivery systems or as drugs for treating certain diseases. We designed three NPs with different charges and modifications with PEG to treat tumors. PDLA-CS, PEG-PLGA-PLL, and PEG-PS/CaP NPs were designed and evaluated to assess NPs fate in vivo and efficacy for treating tumors. Comparison between PEG-modified and non-PEG-modified NPs showed that PEG-modified NPs increased K+ efflux, easily escaped from lysosomes, affected the mitochondria, induced mitochondrial apoptosis, had longer circulation time, and easily targeted tumors. Non-PEG-modified NPs induce the endoplasmic reticulum apoptosis pathway. Comparison between positively and negatively charged NPs showed that negatively charged NPs have less effect on the K+ efflux of normal cells and more effect on the mitochondrial apoptosis of tumor cells. Positively charged NPs accumulated within the tumors and the liver and lungs. These results provide a theoretical basis for future clinical applications. |
| first_indexed | 2024-10-01T07:07:50Z |
| format | Journal Article |
| id | ntu-10356/80669 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:07:50Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/806692020-03-07T11:35:24Z Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma Wang, Qi Sun, Ying Zhang, Zhirong Duan, Yourong School of Chemical and Biomedical Engineering Liver tumors Polymeric therapeutic nanoparticles Apoptosis pathway Cell membrane potential Nanoparticles (NPs) have great potential as drug delivery systems or as drugs for treating certain diseases. We designed three NPs with different charges and modifications with PEG to treat tumors. PDLA-CS, PEG-PLGA-PLL, and PEG-PS/CaP NPs were designed and evaluated to assess NPs fate in vivo and efficacy for treating tumors. Comparison between PEG-modified and non-PEG-modified NPs showed that PEG-modified NPs increased K+ efflux, easily escaped from lysosomes, affected the mitochondria, induced mitochondrial apoptosis, had longer circulation time, and easily targeted tumors. Non-PEG-modified NPs induce the endoplasmic reticulum apoptosis pathway. Comparison between positively and negatively charged NPs showed that negatively charged NPs have less effect on the K+ efflux of normal cells and more effect on the mitochondrial apoptosis of tumor cells. Positively charged NPs accumulated within the tumors and the liver and lungs. These results provide a theoretical basis for future clinical applications. 2016-06-07T05:45:43Z 2019-12-06T13:54:22Z 2016-06-07T05:45:43Z 2019-12-06T13:54:22Z 2015 2015 Journal Article Wang, Q., Sun, Y., Zhang, Z., & Duan, Y. (2015). Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials, 56, 229-240. 0142-9612 https://hdl.handle.net/10356/80669 http://hdl.handle.net/10220/40625 10.1016/j.biomaterials.2015.03.050 193747 en Biomaterials © 2015 Elsevier. |
| spellingShingle | Liver tumors Polymeric therapeutic nanoparticles Apoptosis pathway Cell membrane potential Wang, Qi Sun, Ying Zhang, Zhirong Duan, Yourong Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma |
| title | Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma |
| title_full | Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma |
| title_fullStr | Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma |
| title_full_unstemmed | Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma |
| title_short | Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma |
| title_sort | targeted polymeric therapeutic nanoparticles design and interactions with hepatocellular carcinoma |
| topic | Liver tumors Polymeric therapeutic nanoparticles Apoptosis pathway Cell membrane potential |
| url | https://hdl.handle.net/10356/80669 http://hdl.handle.net/10220/40625 |
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