Microbiomes in respiratory health and disease: An Asia-Pacific perspective
There is currently enormous interest in studying the role of the microbiome in health and disease. Microbiome's role is increasingly being applied to respiratory diseases, in particular COPD, asthma, cystic fibrosis and bronchiectasis. The changes in respiratory microbiomes that occur in these...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2017
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| Online Access: | https://hdl.handle.net/10356/80785 http://hdl.handle.net/10220/42257 |
| _version_ | 1811682777658032128 |
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| author | Chotirmall, Sanjay Haresh Gellatly, Shaan L. Budden, Kurtis F. Mac Aogáin, Micheál Shukla, Shakti D. Wood, David L.A. Hugenholtz, Philip Pethe, Kevin Hansbro, Philip M. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chotirmall, Sanjay Haresh Gellatly, Shaan L. Budden, Kurtis F. Mac Aogáin, Micheál Shukla, Shakti D. Wood, David L.A. Hugenholtz, Philip Pethe, Kevin Hansbro, Philip M. |
| author_sort | Chotirmall, Sanjay Haresh |
| collection | NTU |
| description | There is currently enormous interest in studying the role of the microbiome in health and disease. Microbiome's role is increasingly being applied to respiratory diseases, in particular COPD, asthma, cystic fibrosis and bronchiectasis. The changes in respiratory microbiomes that occur in these diseases and how they are modified by environmental challenges such as cigarette smoke, air pollution and infection are being elucidated. There is also emerging evidence that gut microbiomes play a role in lung diseases through the modulation of systemic immune responses and can be modified by diet and antibiotic treatment. There are issues that are particular to the Asia-Pacific region involving diet and prevalence of specific respiratory diseases. Each of these issues is further complicated by the effects of ageing. The challenges now are to elucidate the cause and effect relationships between changes in microbiomes and respiratory diseases and how to translate these into new treatments and clinical care. Here we review the current understanding and progression in these areas. |
| first_indexed | 2024-10-01T04:02:14Z |
| format | Journal Article |
| id | ntu-10356/80785 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:02:14Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/807852020-11-01T05:16:10Z Microbiomes in respiratory health and disease: An Asia-Pacific perspective Chotirmall, Sanjay Haresh Gellatly, Shaan L. Budden, Kurtis F. Mac Aogáin, Micheál Shukla, Shakti D. Wood, David L.A. Hugenholtz, Philip Pethe, Kevin Hansbro, Philip M. Lee Kong Chian School of Medicine (LKCMedicine) Chronic obstructive pulmonary disease Asthma There is currently enormous interest in studying the role of the microbiome in health and disease. Microbiome's role is increasingly being applied to respiratory diseases, in particular COPD, asthma, cystic fibrosis and bronchiectasis. The changes in respiratory microbiomes that occur in these diseases and how they are modified by environmental challenges such as cigarette smoke, air pollution and infection are being elucidated. There is also emerging evidence that gut microbiomes play a role in lung diseases through the modulation of systemic immune responses and can be modified by diet and antibiotic treatment. There are issues that are particular to the Asia-Pacific region involving diet and prevalence of specific respiratory diseases. Each of these issues is further complicated by the effects of ageing. The challenges now are to elucidate the cause and effect relationships between changes in microbiomes and respiratory diseases and how to translate these into new treatments and clinical care. Here we review the current understanding and progression in these areas. NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) Accepted version 2017-04-13T06:08:06Z 2019-12-06T13:58:53Z 2017-04-13T06:08:06Z 2019-12-06T13:58:53Z 2017 Journal Article Chotirmall, S. H., Gellatly, S. L., Budden, K. F., Mac Aogáin, M., Shukla, S. D., Wood, D. L. A., et al. (2017). Microbiomes in respiratory health and disease: An Asia-Pacific perspective. Respirology, 22(2), 240-250. 1323-7799 https://hdl.handle.net/10356/80785 http://hdl.handle.net/10220/42257 10.1111/resp.12971 en Respirology © 2017 Asian Pacific Society of Respirology. This is the author created version of a work that has been peer reviewed and accepted for publication by Respirology, Asian Pacific Society of Respirology. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [ttp://dx.doi.org/10.1111/resp.12971]. 33 p. application/pdf |
| spellingShingle | Chronic obstructive pulmonary disease Asthma Chotirmall, Sanjay Haresh Gellatly, Shaan L. Budden, Kurtis F. Mac Aogáin, Micheál Shukla, Shakti D. Wood, David L.A. Hugenholtz, Philip Pethe, Kevin Hansbro, Philip M. Microbiomes in respiratory health and disease: An Asia-Pacific perspective |
| title | Microbiomes in respiratory health and disease: An Asia-Pacific perspective |
| title_full | Microbiomes in respiratory health and disease: An Asia-Pacific perspective |
| title_fullStr | Microbiomes in respiratory health and disease: An Asia-Pacific perspective |
| title_full_unstemmed | Microbiomes in respiratory health and disease: An Asia-Pacific perspective |
| title_short | Microbiomes in respiratory health and disease: An Asia-Pacific perspective |
| title_sort | microbiomes in respiratory health and disease an asia pacific perspective |
| topic | Chronic obstructive pulmonary disease Asthma |
| url | https://hdl.handle.net/10356/80785 http://hdl.handle.net/10220/42257 |
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