Transforming growth factor β and severe asthma: A perfect storm
Asthma is a chronic inflammatory airway disease involving complex interplay between resident and infiltrative cells, which in turn are regulated by a wide range of host mediators. Identifying useful biomarkers correlating with clinical symptoms and degree of airway obstruction remain important to ef...
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2017
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| Online Access: | https://hdl.handle.net/10356/80790 http://hdl.handle.net/10220/42243 |
| _version_ | 1811685449346842624 |
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| author | Al-Alawi, Mazen Hassan, Tidi Chotirmall, Sanjay Haresh |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Al-Alawi, Mazen Hassan, Tidi Chotirmall, Sanjay Haresh |
| author_sort | Al-Alawi, Mazen |
| collection | NTU |
| description | Asthma is a chronic inflammatory airway disease involving complex interplay between resident and infiltrative cells, which in turn are regulated by a wide range of host mediators. Identifying useful biomarkers correlating with clinical symptoms and degree of airway obstruction remain important to effective future asthma treatments. Transforming growth factor β (TGF-β) is a major mediator involved in pro-inflammatory responses and fibrotic tissue remodeling within the asthmatic lung. Its role however, as a therapeutic target remains controversial. The aim of this review is to highlight its role in severe asthma including interactions with adaptive T-helper cells, cytokines and differentiation through regulatory T-cells. Associations between TGF-β and eosinophils will be addressed and the effects of genetic polymorphisms of the TGF-β1 gene explored in the context of asthma. We highlight TGF-β1 as a potential future therapeutic target in severe asthma including its importance in identifying emerging clinical phenotypes in asthmatic subjects who may be suitable for individualized therapy through TGF-β modulation. |
| first_indexed | 2024-10-01T04:44:42Z |
| format | Journal Article |
| id | ntu-10356/80790 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:44:42Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/807902020-11-01T05:18:57Z Transforming growth factor β and severe asthma: A perfect storm Al-Alawi, Mazen Hassan, Tidi Chotirmall, Sanjay Haresh Lee Kong Chian School of Medicine (LKCMedicine) Asthma TGF-β Asthma is a chronic inflammatory airway disease involving complex interplay between resident and infiltrative cells, which in turn are regulated by a wide range of host mediators. Identifying useful biomarkers correlating with clinical symptoms and degree of airway obstruction remain important to effective future asthma treatments. Transforming growth factor β (TGF-β) is a major mediator involved in pro-inflammatory responses and fibrotic tissue remodeling within the asthmatic lung. Its role however, as a therapeutic target remains controversial. The aim of this review is to highlight its role in severe asthma including interactions with adaptive T-helper cells, cytokines and differentiation through regulatory T-cells. Associations between TGF-β and eosinophils will be addressed and the effects of genetic polymorphisms of the TGF-β1 gene explored in the context of asthma. We highlight TGF-β1 as a potential future therapeutic target in severe asthma including its importance in identifying emerging clinical phenotypes in asthmatic subjects who may be suitable for individualized therapy through TGF-β modulation. Accepted version 2017-04-07T07:27:07Z 2019-12-06T13:58:59Z 2017-04-07T07:27:07Z 2019-12-06T13:58:59Z 2014 Journal Article Al-Alawi, M., Hassan, T., & Chotirmall, S. H. (2014). Transforming growth factor β and severe asthma: A perfect storm. Respiratory Medicine, 108(10), 1409-1423. 0954-6111 https://hdl.handle.net/10356/80790 http://hdl.handle.net/10220/42243 10.1016/j.rmed.2014.08.008 en Respiratory Medicine © 2014 Elsevier Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Respiratory Medicine, Elsevier Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.rmed.2014.08.008]. 53 p. application/pdf |
| spellingShingle | Asthma TGF-β Al-Alawi, Mazen Hassan, Tidi Chotirmall, Sanjay Haresh Transforming growth factor β and severe asthma: A perfect storm |
| title | Transforming growth factor β and severe asthma: A perfect storm |
| title_full | Transforming growth factor β and severe asthma: A perfect storm |
| title_fullStr | Transforming growth factor β and severe asthma: A perfect storm |
| title_full_unstemmed | Transforming growth factor β and severe asthma: A perfect storm |
| title_short | Transforming growth factor β and severe asthma: A perfect storm |
| title_sort | transforming growth factor β and severe asthma a perfect storm |
| topic | Asthma TGF-β |
| url | https://hdl.handle.net/10356/80790 http://hdl.handle.net/10220/42243 |
| work_keys_str_mv | AT alalawimazen transforminggrowthfactorbandsevereasthmaaperfectstorm AT hassantidi transforminggrowthfactorbandsevereasthmaaperfectstorm AT chotirmallsanjayharesh transforminggrowthfactorbandsevereasthmaaperfectstorm |