Lipid-coated polymeric nanoparticles for cancer drug delivery
Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2015
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| Online Access: | https://hdl.handle.net/10356/80915 http://hdl.handle.net/10220/38885 |
| _version_ | 1811692690091278336 |
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| author | Krishnamurthy, Sangeetha Vaiyapuri, Rajendran Zhang, Liangfang Chan, Juliana Maria Shuping |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Krishnamurthy, Sangeetha Vaiyapuri, Rajendran Zhang, Liangfang Chan, Juliana Maria Shuping |
| author_sort | Krishnamurthy, Sangeetha |
| collection | NTU |
| description | Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both polymeric nanoparticles and liposomes, has received attention in recent years. These core/shell type nanoparticles, frequently referred to as lipid–polymer hybrid nanoparticles (LPNs), possess several characteristics that make them highly suitable for drug delivery. This review introduces the formulation methods used to synthesize LPNs and discusses the strategies used to treat cancer, such as by targeting the tumor microenvironment or vasculature. Finally, it discusses the challenges that must be overcome to realize the full potential of LPNs in the clinic. |
| first_indexed | 2024-10-01T06:39:47Z |
| format | Journal Article |
| id | ntu-10356/80915 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:39:47Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/809152023-12-29T06:51:01Z Lipid-coated polymeric nanoparticles for cancer drug delivery Krishnamurthy, Sangeetha Vaiyapuri, Rajendran Zhang, Liangfang Chan, Juliana Maria Shuping School of Chemical and Biomedical Engineering Liposomes Polymeric Nanoparticles Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both polymeric nanoparticles and liposomes, has received attention in recent years. These core/shell type nanoparticles, frequently referred to as lipid–polymer hybrid nanoparticles (LPNs), possess several characteristics that make them highly suitable for drug delivery. This review introduces the formulation methods used to synthesize LPNs and discusses the strategies used to treat cancer, such as by targeting the tumor microenvironment or vasculature. Finally, it discusses the challenges that must be overcome to realize the full potential of LPNs in the clinic. Published version 2015-12-01T08:15:20Z 2019-12-06T14:17:19Z 2015-12-01T08:15:20Z 2019-12-06T14:17:19Z 2015 Journal Article Krishnamurthy, S., Vaiyapuri, R., Zhang, L., & Chan, J. M. (2015). Lipid-coated polymeric nanoparticles for cancer drug delivery. Biomaterials Science, 3(7), 923-936. 2047-4830 https://hdl.handle.net/10356/80915 http://hdl.handle.net/10220/38885 10.1039/C4BM00427B en Biomaterials Science © 2015 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. 14 p. application/pdf |
| spellingShingle | Liposomes Polymeric Nanoparticles Krishnamurthy, Sangeetha Vaiyapuri, Rajendran Zhang, Liangfang Chan, Juliana Maria Shuping Lipid-coated polymeric nanoparticles for cancer drug delivery |
| title | Lipid-coated polymeric nanoparticles for cancer drug delivery |
| title_full | Lipid-coated polymeric nanoparticles for cancer drug delivery |
| title_fullStr | Lipid-coated polymeric nanoparticles for cancer drug delivery |
| title_full_unstemmed | Lipid-coated polymeric nanoparticles for cancer drug delivery |
| title_short | Lipid-coated polymeric nanoparticles for cancer drug delivery |
| title_sort | lipid coated polymeric nanoparticles for cancer drug delivery |
| topic | Liposomes Polymeric Nanoparticles |
| url | https://hdl.handle.net/10356/80915 http://hdl.handle.net/10220/38885 |
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