Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin. Progerin triggers loss of the heterochromatic marker H3K27me3, and premature senescence, which is prevented by telomerase. However, the mechanism...

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Bibliographic Details
Main Authors: Chojnowski, Alexandre, Ong, Peh Fern, Wong, Esther S. M., Lim, John S. Y., Mutalif, Rafidah A., Navasankari, Raju, Dutta, Bamaprasad, Yang, Henry, Liow, Yi Y., Sze, Siu Kwan, Boudier, Thomas, Wright, Graham D., Colman, Alan, Burke, Brian, Stewart, Colin L., Dreesen, Oliver
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2015
Online Access:https://hdl.handle.net/10356/81002
http://hdl.handle.net/10220/39046

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