Efficient DNA-Mediated Electron Transport in Ionic Liquids
Electron conductivity of duplex DNA has promising applications in fabricating DNA based biosensors and electronic devices for biomimic solar cells. However, in aqueous solution DNA-mediated electron transfer (ET) is often far from ideal for these applications. We reported here that in hydrated ionic...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2017
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| Online Access: | https://hdl.handle.net/10356/81324 http://hdl.handle.net/10220/43452 |
| _version_ | 1826128638469210112 |
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| author | Xuan, Shuguang Meng, Zhenyu Wu, Xiangyang Wong, Jiun-Ru Devi, Gitali Yeow, Edwin Kok Lee Shao, Fangwei |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Xuan, Shuguang Meng, Zhenyu Wu, Xiangyang Wong, Jiun-Ru Devi, Gitali Yeow, Edwin Kok Lee Shao, Fangwei |
| author_sort | Xuan, Shuguang |
| collection | NTU |
| description | Electron conductivity of duplex DNA has promising applications in fabricating DNA based biosensors and electronic devices for biomimic solar cells. However, in aqueous solution DNA-mediated electron transfer (ET) is often far from ideal for these applications. We reported here that in hydrated ionic liquids (IL) electron can propagate through 4 nm of duplex DNA, and higher ET efficiency was achieved over longer distance which yielded a noncanonical negative distance decay parameter (γ = −0.02 Å–1). Fluorescence studies and ET efficiency of duplex DNA in IL-D2O revealed that the binding of both cationic and anionic species of hydrated IL in DNA minor groove and the exclusion of water from the DNA hydration layer significantly improved base-pair stacking of duplex DNA to achieve efficient electric conductivity. As an oxidation reaction of nucleic acids, efficient DNA ET observed here suggested that IL could be a promising nonorganic and nonaqueous solvent for redox reactions of biomacromolecules. |
| first_indexed | 2024-10-01T07:28:13Z |
| format | Journal Article |
| id | ntu-10356/81324 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:28:13Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/813242023-02-28T19:22:18Z Efficient DNA-Mediated Electron Transport in Ionic Liquids Xuan, Shuguang Meng, Zhenyu Wu, Xiangyang Wong, Jiun-Ru Devi, Gitali Yeow, Edwin Kok Lee Shao, Fangwei School of Physical and Mathematical Sciences Conductive biomolecule Anthraquinone Electron conductivity of duplex DNA has promising applications in fabricating DNA based biosensors and electronic devices for biomimic solar cells. However, in aqueous solution DNA-mediated electron transfer (ET) is often far from ideal for these applications. We reported here that in hydrated ionic liquids (IL) electron can propagate through 4 nm of duplex DNA, and higher ET efficiency was achieved over longer distance which yielded a noncanonical negative distance decay parameter (γ = −0.02 Å–1). Fluorescence studies and ET efficiency of duplex DNA in IL-D2O revealed that the binding of both cationic and anionic species of hydrated IL in DNA minor groove and the exclusion of water from the DNA hydration layer significantly improved base-pair stacking of duplex DNA to achieve efficient electric conductivity. As an oxidation reaction of nucleic acids, efficient DNA ET observed here suggested that IL could be a promising nonorganic and nonaqueous solvent for redox reactions of biomacromolecules. MOE (Min. of Education, S’pore) Accepted version 2017-07-26T09:24:10Z 2019-12-06T14:28:27Z 2017-07-26T09:24:10Z 2019-12-06T14:28:27Z 2016 Journal Article Xuan, S., Meng, Z., Wu, X., Wong, J.-R., Devi, G., Yeow, E. K. L., et al. (2016). Efficient DNA-Mediated Electron Transport in Ionic Liquids. ACS Sustainable Chemistry & Engineering, 4(12), 6703-6711. https://hdl.handle.net/10356/81324 http://hdl.handle.net/10220/43452 10.1021/acssuschemeng.6b01605 en ACS Sustainable Chemistry & Engineering © 2016 American Chemical Society (ACS). This is the author created version of a work that has been peer reviewed and accepted for publication by ACS Sustainable Chemistry & Engineering, American Chemical Society (ACS). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acssuschemeng.6b01605]. 28 p. application/pdf |
| spellingShingle | Conductive biomolecule Anthraquinone Xuan, Shuguang Meng, Zhenyu Wu, Xiangyang Wong, Jiun-Ru Devi, Gitali Yeow, Edwin Kok Lee Shao, Fangwei Efficient DNA-Mediated Electron Transport in Ionic Liquids |
| title | Efficient DNA-Mediated Electron Transport in Ionic Liquids |
| title_full | Efficient DNA-Mediated Electron Transport in Ionic Liquids |
| title_fullStr | Efficient DNA-Mediated Electron Transport in Ionic Liquids |
| title_full_unstemmed | Efficient DNA-Mediated Electron Transport in Ionic Liquids |
| title_short | Efficient DNA-Mediated Electron Transport in Ionic Liquids |
| title_sort | efficient dna mediated electron transport in ionic liquids |
| topic | Conductive biomolecule Anthraquinone |
| url | https://hdl.handle.net/10356/81324 http://hdl.handle.net/10220/43452 |
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