Long-lived innate IL-17–producing γ/δ T cells modulate antimicrobial epithelial host defense in the colon
Intestinal IL-17–producing cells, including Th17, γ/δ T, and innate lymphoid cells, are differentially distributed along the gastrointestinal tract. In this study, we show that the gut IL-17–producing γ/δ T (γ/δ T17) cells develop before birth and persist in the tissue as long-lived cells with minim...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/81392 http://hdl.handle.net/10220/49069 |
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| author | Abdul Rashid Mohammad Muzaki Soncin, Irene Setiagani, Yolanda Aphrilia Sheng, Jianpeng Tetlak, Piotr Karjalainen, Klaus Ruedl, Christiane |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Abdul Rashid Mohammad Muzaki Soncin, Irene Setiagani, Yolanda Aphrilia Sheng, Jianpeng Tetlak, Piotr Karjalainen, Klaus Ruedl, Christiane |
| author_sort | Abdul Rashid Mohammad Muzaki |
| collection | NTU |
| description | Intestinal IL-17–producing cells, including Th17, γ/δ T, and innate lymphoid cells, are differentially distributed along the gastrointestinal tract. In this study, we show that the gut IL-17–producing γ/δ T (γ/δ T17) cells develop before birth and persist in the tissue as long-lived cells with minimal turnover. Most colon γ/δ T17 cells express, together with Vγ4 and CCR6, the scavenger receptor 2 and are mainly restricted to innate lymphoid follicles in the colon. Colon γ/δ T cells in mice that lack conventional dendritic cells 2 produced increased amounts of IL-17 with concomitant heightened epithelial antimicrobial response, such as the C-type lectins Reg3γ and Reg3β. In the absence of γ/δ T cells or after IL-17 neutralization, this epithelial response was dramatically reduced, underlining the protective role of this unique subpopulation of innate γ/δ T17 cells in the colonic mucosa. |
| first_indexed | 2024-10-01T05:10:15Z |
| format | Journal Article |
| id | ntu-10356/81392 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:10:15Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/813922020-03-07T12:18:09Z Long-lived innate IL-17–producing γ/δ T cells modulate antimicrobial epithelial host defense in the colon Abdul Rashid Mohammad Muzaki Soncin, Irene Setiagani, Yolanda Aphrilia Sheng, Jianpeng Tetlak, Piotr Karjalainen, Klaus Ruedl, Christiane School of Biological Sciences T Cells Colon DRNTU::Science::Biological sciences Intestinal IL-17–producing cells, including Th17, γ/δ T, and innate lymphoid cells, are differentially distributed along the gastrointestinal tract. In this study, we show that the gut IL-17–producing γ/δ T (γ/δ T17) cells develop before birth and persist in the tissue as long-lived cells with minimal turnover. Most colon γ/δ T17 cells express, together with Vγ4 and CCR6, the scavenger receptor 2 and are mainly restricted to innate lymphoid follicles in the colon. Colon γ/δ T cells in mice that lack conventional dendritic cells 2 produced increased amounts of IL-17 with concomitant heightened epithelial antimicrobial response, such as the C-type lectins Reg3γ and Reg3β. In the absence of γ/δ T cells or after IL-17 neutralization, this epithelial response was dramatically reduced, underlining the protective role of this unique subpopulation of innate γ/δ T17 cells in the colonic mucosa. MOE (Min. of Education, S’pore) 2019-07-02T02:45:13Z 2019-12-06T14:29:56Z 2019-07-02T02:45:13Z 2019-12-06T14:29:56Z 2017 Journal Article Abdul Rashid Mohammad Muzaki., Soncin, I., Setiagani, Y. A., Sheng, J., Tetlak, P., Karjalainen, K.,& Ruedl, C. (2017). Long-Lived Innate IL-17–Producing γ/δ T Cells Modulate Antimicrobial Epithelial Host Defense in the Colon. The Journal of Immunology, 199(10), 3691-3699. doi:10.4049/jimmunol.1701053 0022-1767 https://hdl.handle.net/10356/81392 http://hdl.handle.net/10220/49069 10.4049/jimmunol.1701053 en The Journal of Immunology © 2017 The American Association of Immunologists, Inc. All rights reserved. |
| spellingShingle | T Cells Colon DRNTU::Science::Biological sciences Abdul Rashid Mohammad Muzaki Soncin, Irene Setiagani, Yolanda Aphrilia Sheng, Jianpeng Tetlak, Piotr Karjalainen, Klaus Ruedl, Christiane Long-lived innate IL-17–producing γ/δ T cells modulate antimicrobial epithelial host defense in the colon |
| title | Long-lived innate IL-17–producing γ/δ T cells modulate antimicrobial epithelial host defense in the colon |
| title_full | Long-lived innate IL-17–producing γ/δ T cells modulate antimicrobial epithelial host defense in the colon |
| title_fullStr | Long-lived innate IL-17–producing γ/δ T cells modulate antimicrobial epithelial host defense in the colon |
| title_full_unstemmed | Long-lived innate IL-17–producing γ/δ T cells modulate antimicrobial epithelial host defense in the colon |
| title_short | Long-lived innate IL-17–producing γ/δ T cells modulate antimicrobial epithelial host defense in the colon |
| title_sort | long lived innate il 17 producing γ δ t cells modulate antimicrobial epithelial host defense in the colon |
| topic | T Cells Colon DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/81392 http://hdl.handle.net/10220/49069 |
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