Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells

Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells

Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-expressing cells. Four 2A peptides derived from the foot-and-mouth disease virus (F2A), equine rhinitis...

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Bibliographic Details
Main Authors: Chng, Jake, Wang, Tianhua, Nian, Rui, Lau, Ally, Hoi, Kong Meng, Yang, Yuansheng, Ho, Steven C. L., Gagnon, Peter, Bi, Xuezhi
Other Authors: School of Chemical and Biomedical Engineering
Format: Journal Article
Language:English
Published: 2016
Subjects:
monoclonal antibody
2A peptide
furin
CHO
cleavage efficiency
GSG linker
Online Access:https://hdl.handle.net/10356/81450
http://hdl.handle.net/10220/40785

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