IgG Aggregation Mechanism for CHO Cell Lines Expressing Excess Heavy Chains

IgG Aggregation Mechanism for CHO Cell Lines Expressing Excess Heavy Chains

Aggregates in protein therapeutics like IgG monoclonal antibodies (mAb) are detrimental to product safety and efficacy. It has been reported that aggregates form in Chinese hamster ovary (CHO) cell lines expressing greater amount of heavy chain (HC) than light chain (LC). In this study, we observed...

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Bibliographic Details
Main Authors: Ho, Steven C. L., Wang, Tianhua, Song, Zhiwei, Yang, Yuansheng
Other Authors: School of Chemical and Biomedical Engineering
Format: Journal Article
Language:English
Published: 2016
Subjects:
Monoclonal antibody
Chinese hamster ovary cells
BiP
IgG aggregation
Online Access:https://hdl.handle.net/10356/81469
http://hdl.handle.net/10220/40791

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