Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review
Coronary artery disease (CAD) is the most common cardiovascular disease. Early diagnosis of CAD's physiological significance is of utmost importance for guiding individualized risk-tailored treatment strategies. In this paper, we first review the state-of-the-art clinical diagnostic indices to...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/81644 http://hdl.handle.net/10220/40931 |
| _version_ | 1811696659498795008 |
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| author | Zhang, Jun-Mei Zhong, Liang Su, Boyang Wan, Min Yap, Jinq Shya Tham, Jasmine P. L. Chua, Leok Poh Ghista, Dhanjoo N. Tan, Ru San |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Zhang, Jun-Mei Zhong, Liang Su, Boyang Wan, Min Yap, Jinq Shya Tham, Jasmine P. L. Chua, Leok Poh Ghista, Dhanjoo N. Tan, Ru San |
| author_sort | Zhang, Jun-Mei |
| collection | NTU |
| description | Coronary artery disease (CAD) is the most common cardiovascular disease. Early diagnosis of CAD's physiological significance is of utmost importance for guiding individualized risk-tailored treatment strategies. In this paper, we first review the state-of-the-art clinical diagnostic indices to quantify the severity of CAD and the associated invasive and noninvasive imaging technologies in order to quantify the anatomical parameters of diameter stenosis, area stenosis, and hemodynamic indices of coronary flow reserve and fractional flow reserve. With the development of computational technologies and CFD methods, tremendous progress has been made in applying image-based CFD simulation techniques to elucidate the effects of hemodynamics in vascular pathophysiology toward the initialization and progression of CAD. So then, we review the advancements of CFD technologies in patient-specific modeling, involving the development of geometry reconstruction, boundary conditions, and fluid–structure interaction. Next, we review the applications of CFD to stenotic sites, in order to compute their hemodynamic parameters and study the relationship between the hemodynamic conditions and the clinical indices, to thereby assess the amount of viable myocardium and candidacy for percutaneous coronary intervention. Finally, we review the strengths and limitations of current researches of applying CFD to CAD studies. |
| first_indexed | 2024-10-01T07:42:53Z |
| format | Journal Article |
| id | ntu-10356/81644 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:42:53Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/816442020-03-07T13:19:23Z Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review Zhang, Jun-Mei Zhong, Liang Su, Boyang Wan, Min Yap, Jinq Shya Tham, Jasmine P. L. Chua, Leok Poh Ghista, Dhanjoo N. Tan, Ru San School of Mechanical and Aerospace Engineering CFD coronary artery disease (CAD) Coronary artery disease (CAD) is the most common cardiovascular disease. Early diagnosis of CAD's physiological significance is of utmost importance for guiding individualized risk-tailored treatment strategies. In this paper, we first review the state-of-the-art clinical diagnostic indices to quantify the severity of CAD and the associated invasive and noninvasive imaging technologies in order to quantify the anatomical parameters of diameter stenosis, area stenosis, and hemodynamic indices of coronary flow reserve and fractional flow reserve. With the development of computational technologies and CFD methods, tremendous progress has been made in applying image-based CFD simulation techniques to elucidate the effects of hemodynamics in vascular pathophysiology toward the initialization and progression of CAD. So then, we review the advancements of CFD technologies in patient-specific modeling, involving the development of geometry reconstruction, boundary conditions, and fluid–structure interaction. Next, we review the applications of CFD to stenotic sites, in order to compute their hemodynamic parameters and study the relationship between the hemodynamic conditions and the clinical indices, to thereby assess the amount of viable myocardium and candidacy for percutaneous coronary intervention. Finally, we review the strengths and limitations of current researches of applying CFD to CAD studies. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) NMRC (Natl Medical Research Council, S’pore) 2016-07-13T09:00:41Z 2019-12-06T14:35:27Z 2016-07-13T09:00:41Z 2019-12-06T14:35:27Z 2014 Journal Article Zhang, J.-M., Zhong, L., Su, B., Wan, M., Yap, J. S., Tham, J. P. L., et al. (2014). Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review. International Journal for Numerical Methods in Biomedical Engineering, 30(6), 659-680. 2040-7939 https://hdl.handle.net/10356/81644 http://hdl.handle.net/10220/40931 10.1002/cnm.2625 en International Journal for Numerical Methods in Biomedical Engineering © 2014 John Wiley & Sons, Ltd. |
| spellingShingle | CFD coronary artery disease (CAD) Zhang, Jun-Mei Zhong, Liang Su, Boyang Wan, Min Yap, Jinq Shya Tham, Jasmine P. L. Chua, Leok Poh Ghista, Dhanjoo N. Tan, Ru San Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review |
| title | Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review |
| title_full | Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review |
| title_fullStr | Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review |
| title_full_unstemmed | Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review |
| title_short | Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review |
| title_sort | perspective on cfd studies of coronary artery disease lesions and hemodynamics a review |
| topic | CFD coronary artery disease (CAD) |
| url | https://hdl.handle.net/10356/81644 http://hdl.handle.net/10220/40931 |
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