Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

Itraconazole, a clinically used antifungal drug, was found to possess potent antiangiogenic and anticancer activity that is unique among the azole antifungals. Previous mechanistic studies have shown that itraconazole inhibits the mechanistic target of rapamycin (mTOR) signaling pathway, which is kn...

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Bibliographic Details
Main Authors: Head, Sarah A., Shi, Wei, Zhao, Liang, Gorshkov, Kirill, Pasunooti, Kalyan, Chen, Yue, Deng, Zhiyou, Li, Ruo-jing, Shim, Joong Sup, Tan, Wenzhi, Hartung, Thomas, Zhang, Jin, Zhao, Yingming, Colombini, Marco, Liu, Jun O.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2016
Subjects:
Mitochondria
Metabolism
Itraconazole
VDAC1
Angiogenesis
Online Access:https://hdl.handle.net/10356/81688
http://hdl.handle.net/10220/39676

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