Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study
In this Letter, photoacoustic-guided Raman spectroscopy (PARS) is proposed for a fast depth-resolved Raman measurement with accurate depth localization. The approach was experimentally demonstrated to receive both photoacoustic and Raman signals from a three-layer agar phantom based on a developed s...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/10356/81715 http://hdl.handle.net/10220/39610 |
| _version_ | 1826111916594954240 |
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| author | Gao, Fei Ong, Yi Hong Li, Gaoming Feng, Xiaohua Liu, Quan Zheng, Yuanjin |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Gao, Fei Ong, Yi Hong Li, Gaoming Feng, Xiaohua Liu, Quan Zheng, Yuanjin |
| author_sort | Gao, Fei |
| collection | NTU |
| description | In this Letter, photoacoustic-guided Raman spectroscopy (PARS) is proposed for a fast depth-resolved Raman measurement with accurate depth localization. The approach was experimentally demonstrated to receive both photoacoustic and Raman signals from a three-layer agar phantom based on a developed synergic photoacoustic-Raman probe, showing strong depth correlation and achieving magnitude of faster operation speed due to photoacoustic time-of-flight measurement and guidance, compared with the conventional depth-resolved Raman spectroscopy method. In addition, further combination with advanced optical-focusing techniques in biological-scattering medium could potentially enable the proposed approach for cancer diagnostics with both tight and fast optical focusing at the desired depth of tumor. |
| first_indexed | 2024-10-01T02:58:41Z |
| format | Journal Article |
| id | ntu-10356/81715 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:58:41Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/817152020-03-07T11:35:21Z Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study Gao, Fei Ong, Yi Hong Li, Gaoming Feng, Xiaohua Liu, Quan Zheng, Yuanjin School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering Raman spectroscopy Depth-resolved In this Letter, photoacoustic-guided Raman spectroscopy (PARS) is proposed for a fast depth-resolved Raman measurement with accurate depth localization. The approach was experimentally demonstrated to receive both photoacoustic and Raman signals from a three-layer agar phantom based on a developed synergic photoacoustic-Raman probe, showing strong depth correlation and achieving magnitude of faster operation speed due to photoacoustic time-of-flight measurement and guidance, compared with the conventional depth-resolved Raman spectroscopy method. In addition, further combination with advanced optical-focusing techniques in biological-scattering medium could potentially enable the proposed approach for cancer diagnostics with both tight and fast optical focusing at the desired depth of tumor. Accepted version 2016-01-07T04:36:13Z 2019-12-06T14:36:44Z 2016-01-07T04:36:13Z 2019-12-06T14:36:44Z 2015 Journal Article Gao, F., Ong, Y. H., Li, G., Feng, X., Liu, Q., & Zheng, Y. (2015). Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study. Optics Letters, 40(15), 3568-3571. 0146-9592 https://hdl.handle.net/10356/81715 http://hdl.handle.net/10220/39610 10.1364/OL.40.003568 en Optics Letters © 2015 Optical Society of America. This paper was published in Optics Letters and is made available as an electronic reprint (preprint) with permission of Optical Society of America. The published version is available at: [http://dx.doi.org/10.1364/OL.40.003568]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 5 p. application/pdf |
| spellingShingle | Raman spectroscopy Depth-resolved Gao, Fei Ong, Yi Hong Li, Gaoming Feng, Xiaohua Liu, Quan Zheng, Yuanjin Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study |
| title | Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study |
| title_full | Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study |
| title_fullStr | Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study |
| title_full_unstemmed | Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study |
| title_short | Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study |
| title_sort | fast photoacoustic guided depth resolved raman spectroscopy a feasibility study |
| topic | Raman spectroscopy Depth-resolved |
| url | https://hdl.handle.net/10356/81715 http://hdl.handle.net/10220/39610 |
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