Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA
Skin cancer is a common, low-grade cancerous (malignant) growth of the skin. It starts from cells that begin as normal skin cells and transform into those with the potential to reproduce in an out-of-control manner. Cancer develops when DNA, the molecule found in cells that encodes genetic informati...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/10356/81742 http://hdl.handle.net/10220/39671 |
| _version_ | 1826117805824540672 |
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| author | Namazi, Hamidreza Kulish, Vladimir V. Delaviz, Fatemeh Delaviz, Ali |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Namazi, Hamidreza Kulish, Vladimir V. Delaviz, Fatemeh Delaviz, Ali |
| author_sort | Namazi, Hamidreza |
| collection | NTU |
| description | Skin cancer is a common, low-grade cancerous (malignant) growth of the skin. It starts from cells that begin as normal skin cells and transform into those with the potential to reproduce in an out-of-control manner. Cancer develops when DNA, the molecule found in cells that encodes genetic information, becomes damaged and the body cannot repair the damage. A DNA walk of a genome represents how the frequency of each nucleotide of a pairing nucleotide couple changes locally. In this research in order to diagnose the skin cancer, first DNA walk plots of genomes of patients with skin cancer were generated. Then, the data so obtained was checked for complexity by computing the fractal dimension. Furthermore, the Hurst exponent has been employed in order to study the correlation of damaged DNA. By analysing different samples it has been found that the damaged DNA sequences are exhibiting higher degree of complexity and less correlation compared to normal DNA sequences. This investigation confirms that this method can be used for diagnosis of skin cancer. The method discussed in this research is useful not only for diagnosis of skin cancer but can be applied for diagnosis and growth analysis of different types of cancers. |
| first_indexed | 2024-10-01T04:33:21Z |
| format | Journal Article |
| id | ntu-10356/81742 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:33:21Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/817422023-03-04T17:14:52Z Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA Namazi, Hamidreza Kulish, Vladimir V. Delaviz, Fatemeh Delaviz, Ali School of Mechanical and Aerospace Engineering Skin cancer DNA walk Fractal dimension The Hurst exponent Damaged DNA Skin cancer is a common, low-grade cancerous (malignant) growth of the skin. It starts from cells that begin as normal skin cells and transform into those with the potential to reproduce in an out-of-control manner. Cancer develops when DNA, the molecule found in cells that encodes genetic information, becomes damaged and the body cannot repair the damage. A DNA walk of a genome represents how the frequency of each nucleotide of a pairing nucleotide couple changes locally. In this research in order to diagnose the skin cancer, first DNA walk plots of genomes of patients with skin cancer were generated. Then, the data so obtained was checked for complexity by computing the fractal dimension. Furthermore, the Hurst exponent has been employed in order to study the correlation of damaged DNA. By analysing different samples it has been found that the damaged DNA sequences are exhibiting higher degree of complexity and less correlation compared to normal DNA sequences. This investigation confirms that this method can be used for diagnosis of skin cancer. The method discussed in this research is useful not only for diagnosis of skin cancer but can be applied for diagnosis and growth analysis of different types of cancers. MOE (Min. of Education, S’pore) Published version 2016-01-12T06:26:18Z 2019-12-06T14:39:35Z 2016-01-12T06:26:18Z 2019-12-06T14:39:35Z 2015 Journal Article Namazi, H., Kulish, V. V., Delaviz, F., & Delaviz, A. (2015). Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA. Oncotarget, 6(40), 42623-42631. 1949-2553 https://hdl.handle.net/10356/81742 http://hdl.handle.net/10220/39671 10.18632/oncotarget.6003 26497203 en Oncotarget All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License. 9 p. application/pdf |
| spellingShingle | Skin cancer DNA walk Fractal dimension The Hurst exponent Damaged DNA Namazi, Hamidreza Kulish, Vladimir V. Delaviz, Fatemeh Delaviz, Ali Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA |
| title | Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA |
| title_full | Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA |
| title_fullStr | Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA |
| title_full_unstemmed | Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA |
| title_short | Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA |
| title_sort | diagnosis of skin cancer by correlation and complexity analyses of damaged dna |
| topic | Skin cancer DNA walk Fractal dimension The Hurst exponent Damaged DNA |
| url | https://hdl.handle.net/10356/81742 http://hdl.handle.net/10220/39671 |
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