The role of SON in splicing, development, and disease
SON is a nuclear protein involved in multiple cellular processes including transcription, pre-messenger RNA (mRNA) splicing, and cell cycle regulation. Although SON was discovered 25 years ago, the importance of SON's function was only realized recently when its roles in nuclear organization an...
| Glavni autori: | , , |
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| Format: | Journal Article |
| Jezik: | English |
| Izdano: |
2016
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| Teme: | |
| Online pristup: | https://hdl.handle.net/10356/81807 http://hdl.handle.net/10220/40986 |
| _version_ | 1826122087169785856 |
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| author | Lu, Xinyi Ng, Huck-Hui Bubulya, Paula A. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Lu, Xinyi Ng, Huck-Hui Bubulya, Paula A. |
| author_sort | Lu, Xinyi |
| collection | NTU |
| description | SON is a nuclear protein involved in multiple cellular processes including transcription, pre-messenger RNA (mRNA) splicing, and cell cycle regulation. Although SON was discovered 25 years ago, the importance of SON's function was only realized recently when its roles in nuclear organization and pre-mRNA splicing as well as the influence of these activities in maintaining cellular health were unveiled. Furthermore, SON was implicated to have a key role in stem cells as well as during the onset of various diseases such as cancer, influenza, and hepatitis. Here we review the progress that has been made in studying this multifunctional protein and discuss questions that remain to be answered about SON. |
| first_indexed | 2024-10-01T05:42:46Z |
| format | Journal Article |
| id | ntu-10356/81807 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:42:46Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/818072022-02-16T16:31:17Z The role of SON in splicing, development, and disease Lu, Xinyi Ng, Huck-Hui Bubulya, Paula A. School of Biological Sciences RNA SON SON is a nuclear protein involved in multiple cellular processes including transcription, pre-messenger RNA (mRNA) splicing, and cell cycle regulation. Although SON was discovered 25 years ago, the importance of SON's function was only realized recently when its roles in nuclear organization and pre-mRNA splicing as well as the influence of these activities in maintaining cellular health were unveiled. Furthermore, SON was implicated to have a key role in stem cells as well as during the onset of various diseases such as cancer, influenza, and hepatitis. Here we review the progress that has been made in studying this multifunctional protein and discuss questions that remain to be answered about SON. ASTAR (Agency for Sci., Tech. and Research, S’pore) 2016-07-20T08:22:29Z 2019-12-06T14:40:49Z 2016-07-20T08:22:29Z 2019-12-06T14:40:49Z 2014 Journal Article Lu, X., Ng, H.-H., & Bubulya, P. A. (2014). The role of SON in splicing, development, and disease. Wiley Interdisciplinary Reviews: RNA, 5(5), 637-646. 1757-7004 https://hdl.handle.net/10356/81807 http://hdl.handle.net/10220/40986 10.1002/wrna.1235 24789761 en Wiley Interdisciplinary Reviews: RNA © 2014 John Wiley & Sons, Ltd. |
| spellingShingle | RNA SON Lu, Xinyi Ng, Huck-Hui Bubulya, Paula A. The role of SON in splicing, development, and disease |
| title | The role of SON in splicing, development, and disease |
| title_full | The role of SON in splicing, development, and disease |
| title_fullStr | The role of SON in splicing, development, and disease |
| title_full_unstemmed | The role of SON in splicing, development, and disease |
| title_short | The role of SON in splicing, development, and disease |
| title_sort | role of son in splicing development and disease |
| topic | RNA SON |
| url | https://hdl.handle.net/10356/81807 http://hdl.handle.net/10220/40986 |
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