Spectral estimation optical coherence tomography for axial super-resolution
The depth reflectivity profile of Fourier domain optical coherence tomography (FD-OCT) is estimated from the inverse Fourier transform of the spectral interference signals (interferograms). As a result, the axial resolution is fundamentally limited by the coherence length of the light source. We dem...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2016
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| Online Access: | https://hdl.handle.net/10356/81832 http://hdl.handle.net/10220/41000 |
| _version_ | 1826122028326846464 |
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| author | Liu, Xinyu Chen, Si Cui, Dongyao Yu, Xiaojun Liu, Linbo |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Liu, Xinyu Chen, Si Cui, Dongyao Yu, Xiaojun Liu, Linbo |
| author_sort | Liu, Xinyu |
| collection | NTU |
| description | The depth reflectivity profile of Fourier domain optical coherence tomography (FD-OCT) is estimated from the inverse Fourier transform of the spectral interference signals (interferograms). As a result, the axial resolution is fundamentally limited by the coherence length of the light source. We demonstrate that using the autoregressive spectral estimation technique instead of the inverse Fourier transform, to analyze the spectral interferograms can improve the axial resolution. We name this method spectral estimation OCT (SE-OCT). SE-OCT breaks the coherence length limitation and improves the axial resolution by a factor of up to 4.7 compared with FD-OCT. Furthermore, SE-OCT provides complete sidelobe suppression in the depth point-spread function, further improving the image quality. We demonstrate that these technical advances enables clear identification of corneal endothelium anatomical details ex vivo that cannot be identified using the corresponding FD-OCT. Given that SE-OCT can be implemented in the FD-OCT devices without any hardware changes, the new capabilities provided by SE-OCT are likely to offer immediate improvements to the diagnosis and management of diseases based on OCT imaging. |
| first_indexed | 2024-10-01T05:41:47Z |
| format | Journal Article |
| id | ntu-10356/81832 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:41:47Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/818322020-03-07T11:35:20Z Spectral estimation optical coherence tomography for axial super-resolution Liu, Xinyu Chen, Si Cui, Dongyao Yu, Xiaojun Liu, Linbo School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering Optical coherence tomography Medical optics instrumentation The depth reflectivity profile of Fourier domain optical coherence tomography (FD-OCT) is estimated from the inverse Fourier transform of the spectral interference signals (interferograms). As a result, the axial resolution is fundamentally limited by the coherence length of the light source. We demonstrate that using the autoregressive spectral estimation technique instead of the inverse Fourier transform, to analyze the spectral interferograms can improve the axial resolution. We name this method spectral estimation OCT (SE-OCT). SE-OCT breaks the coherence length limitation and improves the axial resolution by a factor of up to 4.7 compared with FD-OCT. Furthermore, SE-OCT provides complete sidelobe suppression in the depth point-spread function, further improving the image quality. We demonstrate that these technical advances enables clear identification of corneal endothelium anatomical details ex vivo that cannot be identified using the corresponding FD-OCT. Given that SE-OCT can be implemented in the FD-OCT devices without any hardware changes, the new capabilities provided by SE-OCT are likely to offer immediate improvements to the diagnosis and management of diseases based on OCT imaging. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) 2016-07-27T03:39:24Z 2019-12-06T14:41:07Z 2016-07-27T03:39:24Z 2019-12-06T14:41:07Z 2015 Journal Article Liu, X., Chen, S., Cui, D., Yu, X., & Liu, L. (2015). Spectral estimation optical coherence tomography for axial super-resolution. Optics Express, 23(20), 26521-26532. 1094-4087 https://hdl.handle.net/10356/81832 http://hdl.handle.net/10220/41000 10.1364/OE.23.026521 en Optics Express © 2015 Optical Society of America. application/pdf |
| spellingShingle | Optical coherence tomography Medical optics instrumentation Liu, Xinyu Chen, Si Cui, Dongyao Yu, Xiaojun Liu, Linbo Spectral estimation optical coherence tomography for axial super-resolution |
| title | Spectral estimation optical coherence tomography for axial super-resolution |
| title_full | Spectral estimation optical coherence tomography for axial super-resolution |
| title_fullStr | Spectral estimation optical coherence tomography for axial super-resolution |
| title_full_unstemmed | Spectral estimation optical coherence tomography for axial super-resolution |
| title_short | Spectral estimation optical coherence tomography for axial super-resolution |
| title_sort | spectral estimation optical coherence tomography for axial super resolution |
| topic | Optical coherence tomography Medical optics instrumentation |
| url | https://hdl.handle.net/10356/81832 http://hdl.handle.net/10220/41000 |
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