Infection in an aging population
The global population is rapidly aging. Currently, 566 million people are ≥65 years old worldwide, with estimates of nearly 1.5 billion by 2050, particularly in developing countries. Infections constitute a third of mortality in people ≥65 years old. Moreover, lengthening life spans correlate with i...
| Main Authors: | , |
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| Format: | Journal Article |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/10356/81848 http://hdl.handle.net/10220/39736 |
| _version_ | 1826112853429452800 |
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| author | Kline, Kimberly A. Bowdish, Dawn M. E. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Kline, Kimberly A. Bowdish, Dawn M. E. |
| author_sort | Kline, Kimberly A. |
| collection | NTU |
| description | The global population is rapidly aging. Currently, 566 million people are ≥65 years old worldwide, with estimates of nearly 1.5 billion by 2050, particularly in developing countries. Infections constitute a third of mortality in people ≥65 years old. Moreover, lengthening life spans correlate with increased time in hospitals or long-term care facilities and exposure to drug-resistant pathogens. Indeed, the risk of nosocomial infections increases with age, independent of duration spent in healthcare facilities. In this review, we summarize our understanding of how the aging immune system relates to bacterial infections. We highlight the most prevalent infections affecting aging populations including pneumonia, urinary tract infections, and wound infections and make recommendations for future research into infection in aging populations. |
| first_indexed | 2024-10-01T03:13:33Z |
| format | Journal Article |
| id | ntu-10356/81848 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:13:33Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/818482023-02-28T16:58:30Z Infection in an aging population Kline, Kimberly A. Bowdish, Dawn M. E. School of Biological Sciences bacterial colonization pneumonia The global population is rapidly aging. Currently, 566 million people are ≥65 years old worldwide, with estimates of nearly 1.5 billion by 2050, particularly in developing countries. Infections constitute a third of mortality in people ≥65 years old. Moreover, lengthening life spans correlate with increased time in hospitals or long-term care facilities and exposure to drug-resistant pathogens. Indeed, the risk of nosocomial infections increases with age, independent of duration spent in healthcare facilities. In this review, we summarize our understanding of how the aging immune system relates to bacterial infections. We highlight the most prevalent infections affecting aging populations including pneumonia, urinary tract infections, and wound infections and make recommendations for future research into infection in aging populations. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Accepted version 2016-01-21T03:54:59Z 2019-12-06T14:41:29Z 2016-01-21T03:54:59Z 2019-12-06T14:41:29Z 2015 Journal Article Kline, K. A., & Bowdish, D. M. E. (2016). Infection in an aging population. Current Opinion in Microbiology, 29, 63-67. 1369-5274 https://hdl.handle.net/10356/81848 http://hdl.handle.net/10220/39736 10.1016/j.mib.2015.11.003 en Current Opinion in Microbiology © 2015 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Current Opinion in Microbiology, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.mib.2015.11.003]. 10 p. application/pdf |
| spellingShingle | bacterial colonization pneumonia Kline, Kimberly A. Bowdish, Dawn M. E. Infection in an aging population |
| title | Infection in an aging population |
| title_full | Infection in an aging population |
| title_fullStr | Infection in an aging population |
| title_full_unstemmed | Infection in an aging population |
| title_short | Infection in an aging population |
| title_sort | infection in an aging population |
| topic | bacterial colonization pneumonia |
| url | https://hdl.handle.net/10356/81848 http://hdl.handle.net/10220/39736 |
| work_keys_str_mv | AT klinekimberlya infectioninanagingpopulation AT bowdishdawnme infectioninanagingpopulation |