Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles
Core-shell alginate-poly (lactic-co-glycolic) acid (PLGA) microparticles are potential candidates to improve hydrophilic drug loading while facilitating controlled release. This report studies the influence of the alginate core size on the drug release profile of alginate-PLGA microparticles and its...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2016
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| Online Access: | https://hdl.handle.net/10356/81905 http://hdl.handle.net/10220/39715 |
| _version_ | 1811693101179207680 |
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| author | Lio, Daniel Yeo, David Xu, Chenjie |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Lio, Daniel Yeo, David Xu, Chenjie |
| author_sort | Lio, Daniel |
| collection | NTU |
| description | Core-shell alginate-poly (lactic-co-glycolic) acid (PLGA) microparticles are potential candidates to improve hydrophilic drug loading while facilitating controlled release. This report studies the influence of the alginate core size on the drug release profile of alginate-PLGA microparticles and its size. Microparticles are synthesized through double-emulsion fabrication via a concurrent ionotropic gelation and solvent extraction. The size of alginate core ranges from approximately 10, 50, to 100 μm when the emulsification method at the first step is homogenization, vortexing, or magnetic stirring, respectively. The second step emulsification for all three conditions is performed with magnetic stirring. Interestingly, although the alginate core has different sizes, alginate-PLGA microparticle diameter does not change. However, drug release profiles are dramatically different for microparticles comprising different-sized alginate cores. Specifically, taking calcein as a model drug, microparticles containing the smallest alginate core (10 μm) show the slowest release over a period of 26 days with burst release less than 1 %. |
| first_indexed | 2024-10-01T06:46:19Z |
| format | Journal Article |
| id | ntu-10356/81905 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:46:19Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/819052023-12-29T06:51:12Z Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles Lio, Daniel Yeo, David Xu, Chenjie School of Chemical and Biomedical Engineering Drug delivery Core-shell structure Alginate-PLGA microparticles Core-shell alginate-poly (lactic-co-glycolic) acid (PLGA) microparticles are potential candidates to improve hydrophilic drug loading while facilitating controlled release. This report studies the influence of the alginate core size on the drug release profile of alginate-PLGA microparticles and its size. Microparticles are synthesized through double-emulsion fabrication via a concurrent ionotropic gelation and solvent extraction. The size of alginate core ranges from approximately 10, 50, to 100 μm when the emulsification method at the first step is homogenization, vortexing, or magnetic stirring, respectively. The second step emulsification for all three conditions is performed with magnetic stirring. Interestingly, although the alginate core has different sizes, alginate-PLGA microparticle diameter does not change. However, drug release profiles are dramatically different for microparticles comprising different-sized alginate cores. Specifically, taking calcein as a model drug, microparticles containing the smallest alginate core (10 μm) show the slowest release over a period of 26 days with burst release less than 1 %. Published version 2016-01-19T07:48:21Z 2019-12-06T14:42:46Z 2016-01-19T07:48:21Z 2019-12-06T14:42:46Z 2016 Journal Article Lio, D., Yeo, D., & Xu, C. (2016). Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles. Nanoscale Research Letters, 11(1), 9-. 1931-7573 https://hdl.handle.net/10356/81905 http://hdl.handle.net/10220/39715 10.1186/s11671-015-1222-7 26745977 en Nanoscale Research Letters © 2016 Lio et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. 6 p. application/pdf |
| spellingShingle | Drug delivery Core-shell structure Alginate-PLGA microparticles Lio, Daniel Yeo, David Xu, Chenjie Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles |
| title | Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles |
| title_full | Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles |
| title_fullStr | Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles |
| title_full_unstemmed | Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles |
| title_short | Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles |
| title_sort | control of alginate core size in alginate poly lactic co glycolic acid microparticles |
| topic | Drug delivery Core-shell structure Alginate-PLGA microparticles |
| url | https://hdl.handle.net/10356/81905 http://hdl.handle.net/10220/39715 |
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