The Impact of Immunosenescence on Pulmonary Disease
The global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred. Key facets of advancing age include genomic instability, telomere shortening, epige...
| Main Authors: | , |
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| Format: | Journal Article |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/10356/81927 http://hdl.handle.net/10220/39733 |
| _version_ | 1811686909561274368 |
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| author | Murray, Michelle A. Chotirmall, Sanjay Haresh |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Murray, Michelle A. Chotirmall, Sanjay Haresh |
| author_sort | Murray, Michelle A. |
| collection | NTU |
| description | The global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred. Key facets of advancing age include genomic instability, telomere shortening, epigenetic changes, and declines in immune function termed immunosenescence. Immunosenescence and its associated chronic low grade systemic “inflamm-aging” contribute to the development and progression of pulmonary disease in older individuals. These physiological processes predispose to pulmonary infection and confer specific and unique clinical phenotypes observed in chronic respiratory disease including late-onset asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. Emerging concepts of the gut and airway microbiome further complicate the interrelationship between host and microorganism particularly from an immunological perspective and especially so in the setting of immunosenescence. This review focuses on our current understanding of the aging process, immunosenescence, and how it can potentially impact on various pulmonary diseases and the human microbiome. |
| first_indexed | 2024-10-01T05:07:55Z |
| format | Journal Article |
| id | ntu-10356/81927 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:07:55Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/819272022-02-16T16:28:29Z The Impact of Immunosenescence on Pulmonary Disease Murray, Michelle A. Chotirmall, Sanjay Haresh Lee Kong Chian School of Medicine (LKCMedicine) life expectancy genomic instability The global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred. Key facets of advancing age include genomic instability, telomere shortening, epigenetic changes, and declines in immune function termed immunosenescence. Immunosenescence and its associated chronic low grade systemic “inflamm-aging” contribute to the development and progression of pulmonary disease in older individuals. These physiological processes predispose to pulmonary infection and confer specific and unique clinical phenotypes observed in chronic respiratory disease including late-onset asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. Emerging concepts of the gut and airway microbiome further complicate the interrelationship between host and microorganism particularly from an immunological perspective and especially so in the setting of immunosenescence. This review focuses on our current understanding of the aging process, immunosenescence, and how it can potentially impact on various pulmonary diseases and the human microbiome. Published version 2016-01-21T03:29:10Z 2019-12-06T14:43:15Z 2016-01-21T03:29:10Z 2019-12-06T14:43:15Z 2015 Journal Article Murray, M. A., & Chotirmall, S. H. (2015). The Impact of Immunosenescence on Pulmonary Disease. Mediators of Inflammation, 2015, 692546-. 0962-9351 https://hdl.handle.net/10356/81927 http://hdl.handle.net/10220/39733 10.1155/2015/692546 26199462 en Mediators of Inflammation © 2015 Michelle A. Murray and Sanjay H. Chotirmall. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 11 p. application/pdf |
| spellingShingle | life expectancy genomic instability Murray, Michelle A. Chotirmall, Sanjay Haresh The Impact of Immunosenescence on Pulmonary Disease |
| title | The Impact of Immunosenescence on Pulmonary Disease |
| title_full | The Impact of Immunosenescence on Pulmonary Disease |
| title_fullStr | The Impact of Immunosenescence on Pulmonary Disease |
| title_full_unstemmed | The Impact of Immunosenescence on Pulmonary Disease |
| title_short | The Impact of Immunosenescence on Pulmonary Disease |
| title_sort | impact of immunosenescence on pulmonary disease |
| topic | life expectancy genomic instability |
| url | https://hdl.handle.net/10356/81927 http://hdl.handle.net/10220/39733 |
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