Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations
Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...
| Автори: | , , , , , , , , , , , |
|---|---|
| Інші автори: | |
| Формат: | Journal Article |
| Мова: | English |
| Опубліковано: |
2016
|
| Предмети: | |
| Онлайн доступ: | https://hdl.handle.net/10356/81961 http://hdl.handle.net/10220/41065 |