Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum
Rannpháirtithe: School of Biological Sciences
Formáid: Journal Article
Teanga:English
Foilsithe / Cruthaithe: 2016
Ábhair:
Eukaryotic initiation factor
glutamic acid
Rochtain ar líne:https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

Ar líne

https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

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